The effect of pain-induced emotional stress (PIES) on the contractile function of rat papillary muscle removed 2 h after the end of exposure to stress was studied. The velocity and amplitude of contraction and also the velocity of relaxation of the myocardium of animals exposed to PIES were reduced by more than 40%, whereas the positive inotropic effect of a high frequency of contraction was reduced by 75–86% and adrenergic reactivity was reduced about by half, although the maximal effort developed during isometric contraction was unchanged. It is suggested that during PIES a disturbance develops in the calcium transport system in the membranes and in the sarcolemmal adrenoreceptor-adenylate cyclase system.
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Meerson, F.Z., Gorina, M.S., Zeland, A.M. et al. Effect of pain-induced emotional stress on the contractile function of heart muscle and its sensitivity to noradrenalin. Bull Exp Biol Med 88, 1252–1254 (1979). https://doi.org/10.1007/BF00835563
- contractile function of the heart
- calcium transport