Lipid peroxidation in a focus of hyperactivity in the rat cerebral cortex
Pathological Physiology and General Pathology
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Abstract
It is shown that lipid peroxidation (LPO) can participate in the mechanism of development of paroxysmal activity in the rat cerebral cortex. The appearance of epileptic activity as a result of application of the sodium salt of penicillin to the surface of the sensomotor cortex led to a sharp rise in LPO products in the fraction of unpurified synaptosomes isolated from a focus of hyperactivity. Preliminary injection of the antioxidant α-tocopherol into rats abolished the LPO activation effect and considerably reduced the number of paroxysms recorded on the electrocorticogram during existence of the focus.
Key Words
generator of pathologically enhanced excitation cortical epileptic focus penicillin eortical synaptosomes lipid peroxidation α-tocopherol antiepileptic actionPreview
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© Plenum Publishing Corporation 1980