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Induction of malignant tumors in mice by methylcholanthrene bound covalently with bovine serum albumin

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Abstract

The carcinogenic properties of 3-methylcholanthrene, covalently (by means of bisdiazotized benzidine) bound to protein, were studied in experiments on mice. It was shown that binding with protein in this way does not abolish carcinogenic activity: Sarcomas developed rapidly at the sites of subcutaneous injection of the conjugate. For this reason, immunization of animals with conjugated 3-methyl-cholanthrene-protein antigen in order to obtain antibodies specifically binding the carcinogen is difficult.

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Kovalev, I.E., Kolesnichenko, T.S. & Polevaya, O.Y. Induction of malignant tumors in mice by methylcholanthrene bound covalently with bovine serum albumin. Bull Exp Biol Med 89, 338–339 (1980). https://doi.org/10.1007/BF00834246

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Key Words

  • carcinogen
  • carcinogen-protein conjugate
  • antibodies