The Italian Journal of Neurological Sciences

, Volume 19, Issue 3, pp 133–149

Meningeal metastases: clinical aspects and diagnosis

  • F. Formaglio
  • A. Caraceni


The authors review the clinical and diagnostic aspects involved in leptomeningeal disease due to solid tumours, leukaemias and lymphomas. The importance of the combination of clinical findings with cerebral spinal fluid (CSF) examination and imaging studies in making an early diagnosis is underlined. The raising prevalence of this complication of systemic cancer deserves specific attention on the part of neurologists involved in consultation liason with general medicine and oncology.


Gli Autori revisionano gli aspetti clinici e strumentali coinvolti nella diagnosi di diffusione meningea sia di tumori solidi che di leucemie o linfomi. Viene sottolineata l'importanza dell' associazione di reperti clinici, esame del liquor cefalorachidiano e dati radiologici per consentire una diagnosi precoce. La crescente prevalenza di questa complicazione del cancro disseminato richiede particolare attenzione da parte del neurologo impeganto nella consultazione in medicina generale e in oncologia.

Key words

Leptomeningeal disease Leptomeningeal metastases Diagnosis Meningeal carcinomatosis Cancer complications 


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Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • F. Formaglio
    • 1
  • A. Caraceni
    • 2
  1. 1.Neurology DepartmentScientific Institute San Raffaele “Ville Turro”MilanoItaly
  2. 2.Neurology Unit Paintherapy and Palliative Care DivisionNational Cancer InstituteMilanoItaly

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