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Journal of Neurology

, Volume 239, Supplement 1, pp S17–S21 | Cite as

Retinal dopaminergic receptor affinity and ocular pharmacokinetic profile of piribedil

  • P. Lapalus
  • P. Denis
  • M. Drici
  • D. Fredj-Reygrobellet
  • P. P. Elena
Article
  • 37 Downloads

Summary

Binding studies on retinal dopamine receptors have revealed the existence of both D1 and D2 receptors. Human retina micro-autoradiographs confirm the distribution of dopaminergic receptors in the plexiform layers. Piribedil, a dopaminergic agonist, is able to bind to D2 receptors, while its metabolite (S584) preferentially displaces D1-specific radioligands. These results demonstrate that piribedil has a dopamine-like pharmacological profile including direct interaction with receptors. When instilled into the rabbit eye, piribedil penetrates rapidly and accumulates in the pigmented epithelia - the iris ciliary body and chorioretina - before being rapidly cleared. Macro-autoradiographs confirm this distribution and show the levels to be compatible with the affinity of piribedil for retinal dopaminergic receptors.

Key words

Human Rabbit Eye Piribedil Binding 

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • P. Lapalus
    • 1
  • P. Denis
    • 2
  • M. Drici
    • 1
  • D. Fredj-Reygrobellet
    • 1
  • P. P. Elena
    • 3
  1. 1.Department of Experimental and Clinical PharmacologyFaculté de MédecineNice CedexFrance
  2. 2.Clinical OphthalmologyHôpital Saint AntoineParisFrance
  3. 3.Iris PharmaLa GaudeFrance

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