Child's Nervous System

, Volume 12, Issue 2, pp 97–99 | Cite as

Concentration of malonic dialdehyde in the cerebrospinal fluid as a measure of the intensity of lipid peroxidation processes in intracranial hypertension in small children

  • Grzegorz Bujok
  • Anna Dyaczyńska-Herman
  • Andrzej Jendryczko
  • Krzysztof Mandat
  • Jacek Sypniewski
Original Paper

Abstract

The authors analyzed the concentration of malonic dialdehyde (MDA) in the cerebrospinal fluid (CSF) of children with intracranial hypertension. For the control group an intracranial pressure (ICP) of 250 mm H2O was taken as a reference point. The concentration of MDA was determined by a method using thiobarbituric acid. In a group of children with ICP values greater than the limiting value, the concentration of malonic dialdehyde was 0.629 mmol/mg protein, while in the control group with an ICP below 250 mm H2O, this value was 0.610 mmol/mg protein. The differences between the two groups were not statistically significant, from the results obtained it can be concluded that the concentration of MDA, as an isolated parameter, does not constitute a good measure of intensity of the lipid peroxidation processes in central nervous system (CNS) tissues, taken as an indicator of their disintegration in cases of hydrocephalus with intracranial hypertension.

Key words

Intracranial hypertension Malonic dialdehyde Cerebrospinal fluid Hydrocephalus 

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References

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    Yamamuschi R (1988) Antioxidant activity of tocopherol on lipid peroxidation and their oxidation producs. Nippon Nogei Kagaku Kaishi 62:163–165Google Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Grzegorz Bujok
    • 1
    • 2
  • Anna Dyaczyńska-Herman
    • 1
    • 2
  • Andrzej Jendryczko
    • 3
  • Krzysztof Mandat
    • 4
  • Jacek Sypniewski
    • 4
  1. 1.Department of AnesthesiologySilesian Medical AcademyKatowicePoland
  2. 2.Clinic of Intensive CareSilesian Medical AcademyKatowicePoland
  3. 3.Department of Chemistry and Drug AnalysisSilesian Medical AcademySosnowiecPoland
  4. 4.Department of Pediatric SurgerySilesian Medical AcademyChorzówPoland

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