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Springer Seminars in Immunopathology

, Volume 21, Issue 3, pp 287–294 | Cite as

Control of immune pathology by IL-10-secreting regulatory T cells

  • Sanna Fowler
  • Fiona Powrie
Article

Keywords

Internal Medicine Immune Pathology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Aranda R, Sydora BC, McAllister PL, Binder SW, Yang HY, Targan SR, Kronenberg M (1997) Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+ CD45RBhigh T cells to SCID recipients. J Immunol 158: 3464Google Scholar
  2. 2.
    Asano M, Toda M, Sakaguchi N, Sakaguchi S (1996) Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 184: 387Google Scholar
  3. 3.
    Asseman A, Mauze S, Leach M, Coffman R, Powrie F (1999) An essential role for interleukin 10 in the function of regulatory T cells which inhibit intestinal inflammation. J Exp Med 190 (7): 995Google Scholar
  4. 4.
    Berg D, Davidson N, Kuhn R, Muller W, Menon S, Holland G, Thompson-Snipes L, Leach MW, Rennick D (1996) Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4+ Th1-like responses. J Clin Invest 98: 1010Google Scholar
  5. 5.
    Bleijs D, Waal-Malefyt R de, Figdor CG, Kooyk Y van (1999) Co-stimulation of T cells results in distinct IL-10 and TNF-α cytokine profiles dependent on binding to ICAM-1, ICAM-2 or ICAM-3. Eur J Immunol 29: 2248Google Scholar
  6. 6.
    Bridoux F, Badou A, Saoudi A, Bernard I, Druet E, Pasquier R, Druet P, Pelletier L (1997) Transforming growth factor beta (TGF-beta)-dependent inhibition of T helper cell 2 (Th2)-induced autoimmunity by self-major histocompatibility complex (MHC) class II-specific, regulatory CD4+ T cell lines. J Exp Med 185: 1769Google Scholar
  7. 7.
    Buer J, Lanoue A, Franzke A, Garcia C, Boehmer H von, Sarukhan A (1998) Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo. J Exp Med 187: 177Google Scholar
  8. 8.
    Burkhart C, Liu GY, Anderton SM, Metzler B, Wraith DC (1999) Peptide induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10. Int Immunol 11: 1625Google Scholar
  9. 9.
    Chen Y, Kuchroo V, Riche J, Hafler DA, Weiner HL (1994) Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265: 1237Google Scholar
  10. 10.
    Ding L, Shevach EM (1992) IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function. J Immunol 148: 3133Google Scholar
  11. 11.
    Duchmann R, Schmitt E, Knolle P, Meyer zum Buschenfelde KH, Neurath M (1996) Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12. Eur J Immunol 26: 934Google Scholar
  12. 12.
    Elson C, Sartor RB, Tennyson GS, Riddell RH (1995) Experimental models of inflammatory bowel disease. Gastroenterology 109: 1344Google Scholar
  13. 13.
    Fiorentino D, Zlotnik A. Vieira P, Mosmann TR, Howard M, Moore KW, O'Garra A (1991) IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Thl cells. J Immunol 146: 3444Google Scholar
  14. 14.
    Gonnella P, Chen Y, Inobe J, Komagata Y, Quartulli M, Weiner HL (1998) In situ immune response in gut-associated lymphoid tissue (GALT) following oral antigen in TCR-transgenic mice. J Immunol 160: 4708Google Scholar
  15. 15.
    Gran G, Piguet PF, Vassalli P, Lambert PH (1989) Tumor-necrosis factor and other cytokines in cerebral malaria: experimental and clinical data. Immunol Rev 112: 49Google Scholar
  16. 16.
    Groux H, Bigler M, Vries JE de, Roncarolo MG (1996) Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J Exp Med 184: 19Google Scholar
  17. 17.
    Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, Vries JE de, Roncarolo MG (1997) A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389: 737Google Scholar
  18. 18.
    Hagenbaugh A, Sharma S, Dubinett SM, Wei SHY, Aranda R, Cheroutre H, Fowell DJ, Binder S, Tsao B, Locksley RM, Moore KW, Kronenberg M (1997) Altered immune responses in interleukin 10 transgenic mice. J Exp Med 185: 2101Google Scholar
  19. 19.
    Han H, Jun HS, Utsugi T, Yoon JW (1996) A new type of CD4+ suppressor T cell completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice. J Autoimmun 9: 331Google Scholar
  20. 20.
    Haneda K, Sano K, Tamura G, Sato T, Habu S, Shirato K (1997) TGF-beta induced by oral tolerance ameliorates experimental tracheal eosinophilia. J Immunol 159: 4484Google Scholar
  21. 21.
    Khoo U, Proctor IE, Macpherson AJ (1997) CD4+ T cell down-regulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens. J Immunol 158: 3626Google Scholar
  22. 22.
    Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W (1993) Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75: 263Google Scholar
  23. 23.
    Kullberg M, Ward JM, Gorelick PL, Caspar P, Hieny S, Cheever A, Jankovic D, Sher A (1998)Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism. Infect Immun 66: 5157Google Scholar
  24. 24.
    Maeda H, Kuwahara H, Ichimura Y, Ohtsuki M, Kurakata S, Shiraishi A (1995) TGF-beta enhances macrophage ability to produce IL-10 in normal and tumor-bearing mice. J Immunol 155; 4926Google Scholar
  25. 25.
    Mason D, Powrie F (1998) Control of immune pathology by regulatory T cells. Curr Opin Immunol 10: 649Google Scholar
  26. 26.
    Matzinger P (1994) Tolerance, danger, and the extended family. Annu Rev Immunol 12: 991Google Scholar
  27. 27.
    Medzhitov R, Janeway CA (1998) An ancient system of host defense. Curr Opin Immunol 10: 12Google Scholar
  28. 28.
    Moore K, O'Garra A, Waal Malefyt R de, Vieira P, Mosmann TR (1993) Interleukin-10. Annu Rev Immunol 11: 165Google Scholar
  29. 29.
    Morrissey P, Charrier K, Braddy S, Liggitt D, Watson JD (1993) CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells. J Exp Med 178: 237Google Scholar
  30. 30.
    Nicholson L, Greer JM, Sobel RA, Lees MB, Kuchroo VK (1995) An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 3: 397Google Scholar
  31. 31.
    Papiernik M, Moraes ML de, Pontoux C, Vasseur F, Penit C (1998) Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int Immunol 10: 371Google Scholar
  32. 32.
    Powrie F, Leach MW, Mauze S, Caddle LB, Coffman RL (1993) Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol 5: 1461Google Scholar
  33. 33.
    Powrie F, Leach MW, Mauze S, Menon S, Caddle LB, Coffman RL (1994) Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1: 553Google Scholar
  34. 34.
    Powrie F, Leach MW (1995) Genetic and spontaneous models of inflammatory bowel disease in rodents: evidence for abnormalities in mucosal immune regulation. Ther Immunol 2: 115Google Scholar
  35. 35.
    Powrie F, Carlino J, Leach MW, Mauze S, Coffman RL (1996) A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RBlow CD4+ T cells. J Exp Med 183: 2669Google Scholar
  36. 36.
    Powrie F, Mauze S, Coffman RL (1997) CD4+ T -cells in the regulation of inflammatory responses in the intestine. Res Immunol 148: 576Google Scholar
  37. 37.
    Read S, Mauze S, Asseman C, Bean A, Coffman R, Powrie F (1998) CD38 CD45RBlow CD4+ T cells: a population of T cells with immune regulatory activities in vitro. Eur J Immunol 28: 3435Google Scholar
  38. 38.
    Rizzo L, Morawetz RA, Miller-Rivero NE, Choi R, Wiggert B, Chan CC, Morse HC 3rd, Nussenblatt RB, Caspi RR (1999) IL-4 and IL-10 are both required for the induction of oral tolerance. J Immunol 162: 2613Google Scholar
  39. 39.
    Seddon B, Mason D (1999) Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4+CD45RC cells and CD4+CD8 thymocytes. J Exp Med 189: 279Google Scholar
  40. 40.
    Steinbrink K, Wolfl M, Jonuleit H, Knop J, Enk AH (1997) Induction of tolerance by IL-10-treated dendritic cells. J Immunol 159: 4772Google Scholar
  41. 41.
    Strober W, Kelsall B, Fuss I, Marth T, Ludviksson B, Ehrhardt R, Neurath M (1997) Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation. Immunol Today 18: 61Google Scholar
  42. 42.
    Sundstedt A, Hoiden I, Rosendahl T, Kalland N, Rooijen N van, Dohlsten M (1997) Immunoregulatory role of IL-10 during superantigen-induced-hyporesponsiveness in vivo. J Immunol 158: 979Google Scholar
  43. 43.
    Suri-Payer E, Amar AZ, Thornton AM, Shevach EM (1998) CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol 160: 1212Google Scholar
  44. 44.
    Taga K, Tosato G (1992) IL-10 inhibits human T cell proliferation and IL-2 production. J Immunol 148: 1143Google Scholar
  45. 45.
    Takahashi T, Kuniyasu Y, Toda M, Sakaguchi N, Itch M, Iwata M, Shimizu J, Sakaguchi S (1998) Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 10: 1969Google Scholar
  46. 46.
    Takeuchi M, Alard P, Streilein JW (1998) TGF-beta promotes immune deviation by altering accessory signals of antigen-presenting cells. J Immunol 160: 1589Google Scholar
  47. 47.
    Thornton A, Shevach EM (1998) CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 188: 287Google Scholar
  48. 48.
    Van Gool S, Vermeiren J, Rafiq K, Lorr K, Boer M de, Ceuppens JL (1999) Blocking CD40 — CD154 and CD80/CD86 — CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production. Eur J Immunol 29: 2367Google Scholar
  49. 49.
    Wahl S (1994) Transforming growth factor beta: the good, the bad, and the ugly. J Exp Med 180: 1587Google Scholar
  50. 50.
    Weiner H (1997) Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol Today 18: 335Google Scholar

Copyright information

© Springer-Verlag 1999

Authors and Affiliations

  • Sanna Fowler
    • 1
  • Fiona Powrie
    • 1
  1. 1.Nuffield Department of Surgery, University of OxfordJohn Radcliffe HospitalOxfordUK

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