Amino Acids

, Volume 1, Issue 2, pp 199–203

Site specificity of protein glycation

  • D. J. Walton
  • B. H. Shilton


The rate of nonenzymatic glycation of a protein amino group is dependent upon a number of factors, such as the accessibility to glucose molecules in solution, and local acid-base catalysis of the rearrangement of the Schiff base that is formed initially. This is illustrated by a study of the site specificity of liver alcohol dehydrogenase, in which an attempt has been made to interpret the data in terms of the three-dimensional structure of the enzyme molecule.


Amino acids Protein Enzyme Glycation Glycosylation 


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • D. J. Walton
    • 1
  • B. H. Shilton
    • 1
  1. 1.Department of BiochemistryQueen's UniversityKingston, OntarioCanada

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