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Action of 7,8-benzoflavone on incidence of skin tumors induced by polycyclic hydrocarbons

  • A. B. Linnik
  • V. A. Koblyakov
Oncology
  • 18 Downloads

Abstract

Tumors were induced in CBA mice or (C57BL×CBA)F1 hybrids by application of benzo-(a) pyrene (BP), 6-methyl-BP, 6-formyl-BP, or 7,12-dimethylbenz (a) anthracene (DMBA) to the dorsal skin. If 7,8-benzoflavone (BF) was mixed with the above compounds it reduced the carcinogenic action of the methyl-substituted hydrocarbons (DMBA and 6-methyl-BP) but did not affect the carcinogenic action of BP itself or of 6-formyl-BP. The inhibitory action of BF on carcinogenesis induced by methyl-substituted hydrocarbons is due, it can tentatively be suggested, to inhibition of oxidation of the methyl group.

Key Words

carcinogenesis carcinogens 7,8-benzoflavone antitumor action 

Literature Cited

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    H. Gelboin, F. Wiebel, and L. Diamond, Science,170, 169 (1970).Google Scholar

Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • A. B. Linnik
  • V. A. Koblyakov

There are no affiliations available

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