Action of 7,8-benzoflavone on incidence of skin tumors induced by polycyclic hydrocarbons

  • A. B. Linnik
  • V. A. Koblyakov


Tumors were induced in CBA mice or (C57BL×CBA)F1 hybrids by application of benzo-(a) pyrene (BP), 6-methyl-BP, 6-formyl-BP, or 7,12-dimethylbenz (a) anthracene (DMBA) to the dorsal skin. If 7,8-benzoflavone (BF) was mixed with the above compounds it reduced the carcinogenic action of the methyl-substituted hydrocarbons (DMBA and 6-methyl-BP) but did not affect the carcinogenic action of BP itself or of 6-formyl-BP. The inhibitory action of BF on carcinogenesis induced by methyl-substituted hydrocarbons is due, it can tentatively be suggested, to inhibition of oxidation of the methyl group.

Key Words

carcinogenesis carcinogens 7,8-benzoflavone antitumor action 

Literature Cited

  1. 1.
    A. Kh. Lopp and G. A. Belitskii, Vopr. Onkol., No. 10, 50 (1975).Google Scholar
  2. 2.
    L. F. Fieser and E. V. Hershberg, J. Am. Chem. Soc.,60, 2542 (1938).Google Scholar
  3. 3.
    H. Gelboin, F. Wiebel, and L. Diamond, Science,170, 169 (1970).Google Scholar

Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • A. B. Linnik
  • V. A. Koblyakov

There are no affiliations available

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