Action of mouse antiserum against isologous aggregated immunoglobulins on transplantation and antitumor immunity
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Mouse antiserum against isologous heat-aggregated immunoglobulins (MAAS), on repeated injection into animals, prolonged the survival of skin allografts, facilitated the development of Moloney sarcoma, reduced the latent period of appearance of tumors, sharply increased the yield of tumors which in most cases led to death of the mice, disturbed the normal age barrier for induction of fibrosarcomas, and sharply reduced the intensity of development of Rauscher leukemia. This effect of MAAS on transplantation and antitumor immunity is immunological in nature.
Key Wordsallograft Moloney sarcoma virus Rauscher leukemia transplantation and antitumor immunity
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- 1.E. V. Gruntenko, Immunity and the Development of Malignant Tumors [in Russian], Novosibirsk (1977).Google Scholar
- 2.A. Ya. Kul'berg, V. V. Khorobrykh, I. A. Tarkhanova, et al., Byull. Éksp. Biol. Med., No. 6, 73 (1974).Google Scholar
- 3.V. V. Khorobrykh, D. R. Kaulen, and T. A. Golovanova, Ontogenez, No. 2, 131 (1978).Google Scholar
- 4.L. N. Chernousova, A. Ya. Kul'berg, S. A. Simonyan, et al., Byull. Éksp. Biol. Med., No. 12, 698 (1977).Google Scholar
- 5.A. C. Allison and L. W. Law, Proc. Soc. Exp. Biol. (New York),127, 207 (1968).Google Scholar
- 6.A. C. Allison and R. B. Taylor, Cancer Res.,27, 703 (1967).Google Scholar
- 7.A. C. Allison, J. H. Monga, and V. Hammond, Nature,255, 746 (1974).Google Scholar
- 8.R. E. Billingham and P. B. Medawar, J. Exp. Biol.,28, 385 (1951).Google Scholar