The parental resistance phenomenon and its genetic regulation
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Abstract
Lymphocytes of (CBA×M523)F1 or (A×M523)F1 mice, if transplanted into CBA or A recipients irradiated in a dose of 1000 rad, react to test antigens (sheep's red cells,Salmonella typhi Vi-antigen) by the formation of only 1/100–1/1000 of the number of antibody-forming cells formed by syngeneic recipients. An intermediate result was observed after transplantation of the same cells into irradiated M523 recipients. Conversely, lymphocytes of (A×CBA)F1, (CBA×C57BL/6)F1, or (A×A.CA)F1 mice gave an equal immune response in syngeneic recipients and in CBA or A recipients. The ability of M523 lymphocytes or their hybrids to give an immune response to sheep's red cells did not differ from the immuno-reactivity of lymphocytes of other lines either in situ or in a syngeneic adoptive system. Hematopoietic stem cells from (CBA×M523)F1 mice formed only 40–50% of the number of colonies in the CBA spleen as in the spleen of syngeneic recipients. It is concluded that the M523 mutation interferes with the proliferation and differentiation of hematopoietic cells and lymphocytes in nonsyngeneic irradiated recipients.
Key Words
allogeneic inhibition hybrid resistance parental resistancePreview
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