Morphofunctional characteristics of pacemaker formations in the atrioventricular valves of the heart
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Multicellular formations responsible for the generation of spontaneous pacemaker activity were found in the cusps of the atrioventricular valves of the rabbit heart by means of a microelectrode technique and electron microscopy. Cells of different morphological structure were found: P cells, cells of the Purkinje type, and transitional cells. These formations were found to have a rich innervation, mainly cholinergic in nature. Definite correlation was found between the morphological structure and electrophysiological parameters of these cells.
Key Wordsatrioventricular valves automatic activity membrane potentials P cells
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