Morphofunctional characteristics of pacemaker formations in the atrioventricular valves of the heart

  • N. N. Beskrovnova
  • V. V. Korolev
  • I. L. Kosharskaya
  • V. A. Makarychev
  • L. S. Ul'yaninskii
Morphology and Pathomorphology


Multicellular formations responsible for the generation of spontaneous pacemaker activity were found in the cusps of the atrioventricular valves of the rabbit heart by means of a microelectrode technique and electron microscopy. Cells of different morphological structure were found: P cells, cells of the Purkinje type, and transitional cells. These formations were found to have a rich innervation, mainly cholinergic in nature. Definite correlation was found between the morphological structure and electrophysiological parameters of these cells.

Key Words

atrioventricular valves automatic activity membrane potentials P cells 


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Literature Cited

  1. 1.
    B. F. Hoffman and P. F. Cranefield, Electrophysiology of the Heart, McGraw-Hill, New York [Russian translation, Moscow (1962)].Google Scholar
  2. 2.
    V. A. Makarychev, I. L. Kosharskaya, and L. S. Ul'yaninskii, Byull. Éksp. Biol. Med., No. 5, 517 (1976).Google Scholar
  3. 3.
    V. V. Sokolov and G. G. Goryun, Arkh. Anat., No. 4, 103 (1976).Google Scholar
  4. 4.
    A. Ya. Khabarova, The Innervation of the Heart and Coronary Vessels [in Russian], Leningrad (1975).Google Scholar
  5. 5.
    C. M. Brooks and Hsin-Hsiang Lu, The Sinoatrial Pacemaker of the Heart, C. C. Thomas, Springfield, Illinois (1972).Google Scholar
  6. 6.
    J. J. Fenoglio, Tuan Duc Pham, A. L. Wit, et al., Circ. Res.,31, 417 (1972).Google Scholar
  7. 7.
    T. N. James, L. Sherf, G. Fine, et al., Circulation,34, 139 (1966).Google Scholar
  8. 8.
    K. Kawamura and T. James, J. Mol. Cell. Cardiol.,3, 31 (1971).Google Scholar
  9. 9.
    J. R. Sommer and E. A. Johnson, Am. J. Cardiol.,25, 184 (1970).Google Scholar
  10. 10.
    W. Trautwein and K. Uchizono, Z. Zellforsch.,61, 96 (1963).Google Scholar
  11. 11.
    T. C. West, J. Pharmacol. Exp. Ther.,115, 283 (1955).Google Scholar
  12. 12.
    A. L. Wit, J. J. Fenoglio, B. M. Wagner, et al., Circ. Res.,32, 731 (1973).Google Scholar
  13. 13.
    A. L. Wit, M. R. Rosen, and B. F. Hoffman, Am. Heart J.,88, 515 (1974).Google Scholar
  14. 14.
    A. L. Wit and P. F. Cranefield, Circ. Res.,38, 85 (1976).Google Scholar

Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • N. N. Beskrovnova
  • V. V. Korolev
  • I. L. Kosharskaya
  • V. A. Makarychev
  • L. S. Ul'yaninskii

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