Bulletin of Experimental Biology and Medicine

, Volume 85, Issue 2, pp 152–154 | Cite as

Effect of o,p-dichlorodiphenyldichloroethane and perthane in vitro on glutathione reductase activity in the adrenals of dogs and guinea pigs

  • V. P. Komissarenko
  • I. S. Chelnakova
  • A. S. Mikosha
Biochemistry and Biophysics


o,p′-Dichlorodiphenyldichloroethane (o,p′-DDD) and Perthane, when added in a concentration of 312 μM to homogenate and cytoplasmic fraction of dog adrenals, activate glutathione reductase. In a concentration of 156 μM, o,p′-DDD and Perthane do not affect glutathione reductase activity of the dog adrenals. When given in vitro, o,p′-DDD and Perthane activate glutathione reductase of the guinea pig adrenals. o,p′-DDD has no effect on glutathione reductase activity of the cytoplasmic fraction of dog liver and kidney, thus confirming the high specificity of its effect on the adrenal cortex.

Key Words

glutathione reductase o,p′-dichlorodiphenyldichloroethane p,p′-diethyldiphenyldi-chloroethane (Perthane) adrenals liver kidneys 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    V. P. Komissarenko, A. Ya. Mestechkina, and A. S. Mikosha, Byull. Éksp. Biol. Med., No. 7, 44 (1974).Google Scholar
  2. 2.
    V. P. Komissarenko and A. G. Reznikov, Probl. Éndokrinol., No. 5, 77 (1969).Google Scholar
  3. 3.
    V. P. Komissarenko, A. G. Reznikov, and V. M. Gordienko, Probl. Éndokrinol., No. 4, 90 (1968).Google Scholar
  4. 4.
    A. S. Mikosha and V. P. Komissarenko, Abstracts of Sectional Proceedings of the 2nd All-Union Biochemical Congress. Section 5 [in Russian], Tashkent (1969), p. 10.Google Scholar
  5. 5.
    A. S. Mikosha and V. P. Komissarenko, Ukr. Biokhim. Zh., No. 3, 311 (1971).Google Scholar
  6. 6.
    S. Bramhall et al., Anal. Biochem.,31, 146 (1969).Google Scholar
  7. 7.
    B. W. Harding and D. H. Nelson, Endocrinology,75, 506 (1964).Google Scholar

Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • V. P. Komissarenko
    • 1
  • I. S. Chelnakova
  • A. S. Mikosha
  1. 1.Academy of Sciences of the Ukrainian SSRUSSR

Personalised recommendations