Comparative study of the action of ethimizole and hydrocortisone on proliferative activity and protein synthesis in epithelial cells of the tongue and liver
Experimental Biology
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Abstract
Unlike hydrocortisone, ethimizole stimulated mitotic activity of the epithelial cells of the tongue and liver 6 h after its administration. The decrease in the number of mitoses in the hepatocytes after 12 h was due to the action of both substances on DNA synthesis and not to a disturbance of the entry of the cells into mitosis. Stimulation of protein synthesis was detected by autoradiographic and biochemical methods following the action of hydrocortisone and ethimizole at the maximum of inhibition of mitosis.
Key Words
hydrocortisone ethimizole proliferative activity protein synthesisPreview
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© Plenum Publishing Corporation 1977