Bulletin of Experimental Biology and Medicine

, Volume 78, Issue 1, pp 737–740

Genesis of arrhythmias and mechanism of electrical defibrillation of the heart

  • E. Cañero
  • C. Cabrera
  • V. An Makarychev
  • I. B. Gribanovskii
  • J. Morlans
Pathological Physiology and General Pathology
  • 18 Downloads

Abstract

Atrial arrhythmias were induced in experiments on dogs by electrical stimulation or by local application of aconitine and methacholine to the atrium. The action of the defibrillator discharge on these arrhythmias was studied. The defibrillator discharge abolished the arrhythmias maintained by the circus movement of the excitation wave over the atria but did not abolish sinus tachycardia or ectopic aconitine tachysystoles. The threshold of the defibrillating effect depends on the existence of micro- or macro-reentries. The mechanism of defibrillation consists of excitation of the atrial myocardium with a consequent decrease in the pathway for the circulation of excitation to below the critical size for maintaining the circus movement of the excitation wave. The action of the defibrillator does not inhibit the automatism of the nomotopic and heterotopic cardiac pacemakers.

Key Words

heart-arrhytymias defibrillation 

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Copyright information

© Consultants Bureau, a division of Plenum Publishing Corporation 1974

Authors and Affiliations

  • E. Cañero
  • C. Cabrera
  • V. An Makarychev
  • I. B. Gribanovskii
  • J. Morlans

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