Bulletin of Experimental Biology and Medicine

, Volume 88, Issue 3, pp 993–996 | Cite as

Interaction between actin-like brain protein and isolated synaptic vesicles

  • Yu. G. Sandalov
  • R. N. Glebov
  • G. N. Kryzhanovskii
  • V. I. Shvets
  • G. V. Tolstikova
Pathological Physiology and General Pathology
Received:
  • 23 Downloads

Abstract

Mg-ATP was shown to increase the light diffusion of a suspension of rat brain synaptic vesicles (SV) in the presence of rat brain actin-like protein (ALP) (superprecipitation reaction). ALP increases the Mg-ATPase activity of SV and also the liberation of endogenous noradrenalin from SV of bovine hypothalamus, which is abolished by cytochalasin B. Glycolipids (gangliosides and cerebrosides) inhibit the superprecipitation reaction. The results are examined from the standpoint of the contractile hypothesis of mediator secretion.

Key Words

brain actin-like protein synaptic vesicles secretion of mediators 
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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Yu. G. Sandalov
  • R. N. Glebov
  • G. N. Kryzhanovskii
    • 1
  • V. I. Shvets
  • G. V. Tolstikova
  1. 1.Academy of Medical Sciences of the USSRUSSR

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