Effect of carbon tetrachloride on RNA metabolism in the rat liver

  • L. A. Voronova
  • S. D. Ivanov
  • M. A. Zabezhinskii
Biochemistry and Biophysics


The effect of systematic administration of carbon tetrachloride (CCl4) to rats on the RNA content in the liver and the intensity of incorporation of the labeled precursor (uridine-H3) into it was investigated. Comparison of the results of morphological and biochemical studies revealed two consecutive stages of the toxic process, terminating in the formation of septal fibrosis. The sharpest changes in rapid RNA turnover in the rat liver were observed during the first 3 months of action of the toxic agent. The disturbance of metabolism also was reflected in a lowered RNA level and changes in the nucleo-cytoplasmic ratio in the tissue of the affected liver.

Key Words

carbon tetrachloride liver total, nuclear, and cytoplasmic RNA RNA turnover 


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Literature Cited

  1. 1.
    G. P. Georgiev, in: Chemistry and Biochemistry of Nucleic Acids [in Russian], Leningrad (1968), p. 74.Google Scholar
  2. 2.
    S. D. Ivanov, L. A. Voronova, M. A. Zabezhinskii, et al., Vopr. Onkol., No. 8, 54 (1974).Google Scholar
  3. 3.
    S. D. Ivanov, L. A. Voronova, M. A. Zabezhinskii, et al., in: Molecular Mechanisms of Carcinogenesis and the Action of Antitumor Agents [in Russian], Leningrad (1974), p. 82.Google Scholar
  4. 4.
    A. A. Pal'tsyn, Byull. Éksp. Biol. Med., No. 4, 34 (1973).Google Scholar
  5. 5.
    D. S. Sarkisov, L. D. Krymskii, K. V. Botsmanov, et al., Byull. Éksp. Biol. Med., No. 5, 113 (1972).Google Scholar
  6. 6.
    R. Doring and L. Rensing, Comp. Biochem. Physiol.,45B, 285 (1973).Google Scholar
  7. 7.
    J. Dulcino, R. Bosco, and W. G. Verly, Clin. Chim. Acta.,8, 58 (1963).Google Scholar
  8. 8.
    A. C. Peacock and C. W. Dingman, Biochemistry (Washington),6, 1818 (1967).Google Scholar
  9. 9.
    M. D. Reuber, J. Nat. Cancer Inst.,45, 1237 (1970).Google Scholar
  10. 10.
    M. D. Reuber and E. L. Glover, J. Nat. Cancer Inst.,44, 419 (1970).Google Scholar
  11. 11.
    H. J. Seitz and W. Tarnowski, Hoppe-Seylers Z. Physiol. Chem.,349, 1800 (1968).Google Scholar
  12. 12.
    G. Schmidt and S. S. Thannhauser, J. Biol. Chem.,161, 83 (1945).Google Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • L. A. Voronova
  • S. D. Ivanov
  • M. A. Zabezhinskii

There are no affiliations available

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