Changes in hemopoiesis in congestive splenomegaly with or without denervation of the spleen

Summary

Following ligation of the splenic vein in two dogs, they showed development of wave-like hemolytic anemia. In one of the two dogs in which the vein was ligated in combination with splenic denervation, the hemolytic anemia manifested itself to a considerably greater degree than was the case in the experiment with the vein ligation alone. A rapid rise in the red cell count occured after splenectomy had been performed in connection with the progressive anemia. In dogs with splenic denervation alone, the development of anemia is connected with the depression of erythropoesis.