On cysts in mice of the low cancer line C57BL

Summary

Autopsy findings revealed cystic changes in the lymph glands observed in old mice of the C57BL line formerly subjected to the test of leukemogenic activity of the brain filtrate of a man who had died of acute leukemia.

The cystic fluid inoculated to newborn mice of the same line gave negative results. In a series of consecutive passages of cellular suspensions there was a development of tumors and cysts in young mice of homologous C57BL line as well as in mice of the CC57BR and CC57W lines. In transplantation of a cell-free material to newborn mice of four different lines (C57BL, CC57BR, CC57W, and C3HA) the cysts usually developed only at a more mature age, whereas in subsequent serial passages of suspensions of cystic walls and tumor from these mice — at the age from 4.5 mo to 18 days.