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Virchows Archiv A

, Volume 413, Issue 4, pp 297–302 | Cite as

Estrogen receptors in gastric adenocarcinoma: A retrospective immunohistochemical analysis

  • Hiroshi Yokozaki
  • Naoki Takekura
  • Atsushi Takanashi
  • Junji Tabuchi
  • Rumi Haruta
  • Eiichi Tahara
Article

Summary

Estrogen receptors (ER) in human gastric carcinomas were examined immunohistochemically using a specific monoclonal antibody to human ER. ER-immunoreactivity (ER-IR) was positive in 30 (27.8%) of the 108 gastric carcinomas examined. ER-IR was located in the nucleus of cancer cells. The incidence of ER-IR positive gastric carcinoma was not significantly different between male and female cases. However, the positive tumour cells were observed in 28 (39.4%) out of the 71 poorly differentiated adenocarcinoma, the incidence being significantly higher than that in well differentiated adenocarcinoma (p<0.01). There was no significant difference in the incidence of ER-IR between scirrhous carcinoma and non-scirrhous poorly differentiated adenocarcinoma. Synchronous expression of ER and epidermal growth factor receptor was found in 8 of the 26 scirrhous carcinomas (30.8%). Patients with ER-IR positive scirrhous gastric carcinomas showed a much worse prognosis than those with ER-IR negative scirrhous carcinomas.

Key words

Estrogen receptor Gastric carcinoma Immunohistochemistry 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Hiroshi Yokozaki
    • 1
  • Naoki Takekura
    • 1
  • Atsushi Takanashi
    • 1
  • Junji Tabuchi
    • 1
  • Rumi Haruta
    • 1
  • Eiichi Tahara
    • 1
  1. 1.Department of PathologyHiroshima University School of MedicineHiroshimaJapan

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