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Hematoporphyrin IX

Physicochemical properties, synthesis, biological activity, and clinical use (review)

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Literature cited

  1. J. L. W. Thudichum, Rep. Med. Off. Privy Council, Vol. 10 (1867), Appendix 7, p. 152.

    Google Scholar 

  2. M. Nencki and N. Siber, Arch. Exp. Pathol. Pharmakol.,24, 430 (1888); M. Nencki and J. Zaleski, Z. PhysioL Chem.,30, 423 (1900).

    Google Scholar 

  3. K. G. Paul, Acta Chem. Scand.,5, 389 (1951).

    Google Scholar 

  4. S. Granick, L. Bogorad, and H. Jaffe, J. Biol. Chem.,202, 801 (1953).

    Google Scholar 

  5. H. Fischer and H. Orth, Die Chemie des Pyrrols, Vol. 2, Akademieverlag, Leipzig (1937), p. 423.

    Google Scholar 

  6. F. G. P. Ferraz, M. E. A. Relvas, and M. J. Halpern, Chem. Abstr.,56, 1703b (1961).

    Google Scholar 

  7. H. Fischer and K. Zeile, Ann. Chem.,468, 98 (1929); H. Fischer and K. O. Dielmann, Ann. Chem.,545, 22 (1940).

    Google Scholar 

  8. V. N. Luzgina, E. I. Filippovich, and R. P. Evstigneeva, Zh. Obshch. Khim.,43, 2672 (1973).

    Google Scholar 

  9. P. L. Ohlsson and K. G. Paul, Biochim. Biophys. Acta,315, 293 (1973).

    Google Scholar 

  10. O. Oster, G. W. Neireiter, and F. R. N. Gurd, Z. Naturforsch.,306, 288.

  11. R. Bases, A. Plearmann, R. Rosh, et al., Cancer (Philadelphia),11, 1119 (1958).

    Google Scholar 

  12. E. Ellfolk and G. Siever, J. Chromatogr.,25, 373 (1966).

    Google Scholar 

  13. M. Doss and H. Bürger, Z. Physiol. Chem.,348, 936 (1967).

    Google Scholar 

  14. D. W. Lamson and T. Yonetani, Anal. Biochem.,52, 647 (1973).

    Google Scholar 

  15. D. W. Lamson, A. F. W. Coulson, and T. Yonetani, Anal. Chem.,45, 2273 (1973).

    Google Scholar 

  16. D. W. Lamson and T. Yonetani, Tetrahedron Lett., No. 50, 5025 (1973).

    Google Scholar 

  17. W. Caughey, J. O. Alben, W. Y. Fujimoto, et al., J. Org. Chem.,31, 2631 (1966).

    Google Scholar 

  18. L. J. Boucher and J. J. Ketz, J. Am. Chem. Soc.,89, 1340 (1967).

    Google Scholar 

  19. K. Paul, Acta Chem. Scand.,4, 1221 (1950).

    Google Scholar 

  20. J. E. Falk, Porphyrins and Metalloporphyrins, 1st ed., Am. Elsevier, New York (1964), p. 134.

    Google Scholar 

  21. C. Rimington, W. H. Lockwood, and R. V. Belcher, Clin. Sci.,35, 211 (1968).

    Google Scholar 

  22. J. T. Slama, H. Smith, C. G. Wilson, et al., J. Am. Chem. Soc.,97, 6556 (1975).

    Google Scholar 

  23. A. A. Kubatiev, Porphyrins, Vitamin B12, and Cancer [in Russian], Tula (1973), p. 37.

  24. D. S. Rassmussen-Taxdal, G. E. Ward, and F. H. J. Figge, Cancer (Philadelphia),8, 78 (1955).

    Google Scholar 

  25. S. Takashi, Jpn. J. Cancer Res.,48, 73 (1957).

    Google Scholar 

  26. K. Bingold, W. Stich, and H. Cramer, Z. Krebsforsch.,57, 653 (1951).

    Google Scholar 

  27. F. H. J. Figge, G. S. Weiland, and O. J. Mangarielo, Proc. Soc. Exp. Biol.,68, 640 (1948).

    Google Scholar 

  28. R. L. Lipson, E. J. Baldes, and A. U. Olsen, J. Nat. Cancer Inst.,26, 1 (1961).

    Google Scholar 

  29. J. Winkelman, J. Nat. Cancer Inst.,27, 1369 (1961).

    Google Scholar 

  30. K. I. Altman and K. Solomon, Nature,187, 1127 (1960).

    Google Scholar 

  31. G. C. H. Peck, H. P. Mack, and F. H. J. Figge, Bull. Maryland Univ. School Med.,38, 124 (1953).

    Google Scholar 

  32. S. Schwartz, K. Absolon, and H. Vermund, Univ. Minn. Med. Bull.,27, 7 (1957).

    Google Scholar 

  33. J. R. Leonard and W. K. Beck, Laryngoscope,81, 365 (1971).

    Google Scholar 

  34. R. L. Lipson, E. J. Baldes, and M. J. Gray, Cancer (Philadelphia),20, 2255 (1967).

    Google Scholar 

  35. D. Sanderson, E. Fontana, R. L. Lipson, et al., Cancer (Philadelphia),30, 1368 (1972).

    Google Scholar 

  36. R. L. Lipson and E. J. Baldes, Arch. Dermatol.,82, 508 (1960).

    Google Scholar 

  37. S. Schwartz, K. Absolon, and H. Vermund, J. Lab. Clin. Med.,46, 949 (1955).

    Google Scholar 

  38. W. L. Fowlks, J. Invest. Dermatol.,32, 233 (1959).

    Google Scholar 

  39. J. D. Spikes and R. A. Staight, Annu. Rev. Phys. Chem.,18, 409 (1967).

    Google Scholar 

  40. J. Diamond, A. F. McDonagh, C. B. Wilson, et al., Lancet,2, 1175 (1972).

    Google Scholar 

  41. W. Hausmann, Wien. Klin. Wochenschr.,22, 1820 (1909).

    Google Scholar 

  42. M. I. Amiragova, N. A. Duzhenkova, N. P. Kruslinskaya, et al., Primary Radiobiological Processes [in Russian], Moscow (1973), p. 169.

  43. I. M. Byteva, G. P. Gurinovich, and O. M. Petsol'd, Biofizika,30, 51 (1975).

    Google Scholar 

  44. H. P. Mack. W. K. Diehe, G. G. Reck, et al., Cancer (Philadelphia),10, 529 (1957).

    Google Scholar 

  45. R. Della Volpe and E. Albertini, Arch. Ital. Patol.,2, 183 (1958).

    Google Scholar 

  46. Juzo Tazaki and Hisahi Furue, Cancer Chemother. Rep., No. 13, 41 (1961).

    Google Scholar 

  47. Nobori Lijima, Kiyoshi Matsuura, Akira Ueno, et al., Cancer Chemother. Rep., No. 13, 47 (1961).

    Google Scholar 

  48. Misao Obika, Morie Sasaki, and Katutaro Tanaka, Japanese Patent No. 1789; US Patent No. 3,004,985.

  49. J. P. Maquet and T. Theophanides, Can. J. Chem.,51, 219 (1973).

    Google Scholar 

  50. P. Waldmeier and H. Sigel, Inorg. Chem.,11, 2174 (1972).

    Google Scholar 

  51. P. Waldmeier and H. Sigel, J. Inorg. Nucl. Chem.,35, 1741 (1973).

    Google Scholar 

  52. J. Hühnerfeld, Z. Ges. Neurol. Psychiat.,54, 799 (1936).

    Google Scholar 

  53. G. E. Shvidler, Sov. Psikhonevrol.,13, No. 5, 77 (1937).

    Google Scholar 

  54. C. L. Hammel-Dupont and S. P. Bessmann, Biochem. Med.,4, 55 (1970).

    Google Scholar 

  55. J. L. Moretti, G. Ringenbach, and P. Blanquet, C. R. Soc. Biol.,165, 1885 (1971).

    Google Scholar 

  56. P. D. Zieve and H. M. Solomon, Am. J. physiol.,210, 1391 (1966).

    Google Scholar 

  57. J. Hühnerfeld, Die biologisch-klinische Bedeutung des Haematoporhrin, Nencke, Leipzig (1941).

    Google Scholar 

  58. I. G. Andrianova et al., in: Questions of Hematology and the Preservation of Blood and Tissues [in Russian], Leningrad (1961), p. 245.

  59. I. G. Andrianova, in: Modern Problems of Hematology and Blood Transfusion [in Russian], Moscow, No. 36 (1964), p. 299.

    Google Scholar 

  60. I. G. Andrianova and L. G. Bogomolova, in: Preparations and Blood Substitutes of the Leningrad Scientific-Research Institute of Hematology and Blood Transfusion (Methodological Handbook for Doctors) [in Russian], Leningrad (1970), p. 55.

  61. B. Lustig, Münch. Med. Wochenschr.,99, 114 (1957).

    Google Scholar 

  62. E. I. Yartsev, S. D. Novosel'tseva, G. V. Kirillova, et al., Radiobiologiya,15, 277 (1975).

    Google Scholar 

  63. M. K. Locken, Radiology,69, 201 (1957).

    Google Scholar 

  64. G. Cittadini, L. Lanferdini, and G. Mancini, Chem. Abstr.,74, 20102 (1971).

    Google Scholar 

  65. L. Cohen and S. Schwartz, Cancer Res.,26, 1769 (1966).

    Google Scholar 

  66. R. M. Nalbandyan, Biol. Zh. Arm.,29, 37 (1976).

    Google Scholar 

  67. J. Model and S. Schwartz, Proc. Soc. Exp. Biol.,116, 399 (1964).

    Google Scholar 

  68. R. Grandpierre, P. Faltot, Y. Linquette, et al., Presse Therm. (Clin.),109, 92 (1972).

    Google Scholar 

  69. R. Altschul, Exp. Mol. Pathol.,2, 261 (1963).

    Google Scholar 

  70. H. M. Solomon, J. Pharmacol. Exp. Ther.,134, 251 (1964).

    Google Scholar 

  71. H. F. Blum and N. Pace, Br. J. Derm.,49, 465 (1937).

    Google Scholar 

  72. F. H. J. Figge and R. Wichterman, Science,122, 468 (1955).

    Google Scholar 

  73. F. Sellich, M. Pantlischko, and J. Zakowski, Naturwissenschaften,44, 586 (1957).

    Google Scholar 

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Translated from Khimiko-Farmatsevticheskii Zhurnal. Vol. 11, No. 5, pp. 26–35, May, 1977.

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Luzgina, V.N., Filippovich, E.I. & Evstigneeva, R.P. Hematoporphyrin IX. Pharm Chem J 11, 613–620 (1977). https://doi.org/10.1007/BF00780815

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