Journal of Bioenergetics and Biomembranes

, Volume 24, Issue 1, pp 63–69 | Cite as

The mitochondrial benzodiazepine receptor: Evidence for association with the voltage-dependent anion channel (VDAC)

  • Maureen W. McEnery
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Abstract

Specific, high-affinity receptors for numerous drugs have recently been localized to mitochondrial membrane proteins. This review discusses the association of the mitochondrial receptor for benzodiazepines (mBzR) with the voltage-dependent anion channel (VDAC), indicating a possible auxiliary role for VDAC as a putative drug binding protein. The proposed subunit composition of the purified mBzR complex isolated from rat kidney mitochondria includes VDAC, which functions as a recognition site for benzodiazepines (e.g., flunitrazepam), the adenine nucleotide carrier (ADC), and an 18 kDa outer membrane protein identified by covalent labelling with the mBzR antagonists isoquinoline carboxamides (e.g., PK 14105).

Key words

Mitochondria receptor benzodiazepine isoquinoline carboxamide anion channel 
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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Maureen W. McEnery
    • 1
  1. 1.Department of NeuroscienceThe Johns Hopkins University School of MedicineBaltimore

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