Journal of Bioenergetics and Biomembranes

, Volume 22, Issue 4, pp 571–592 | Cite as

Binding protein-dependent transport systems

  • C. F. Higgins
  • S. C. Hyde
  • M. M. Mimmack
  • U. Gileadi
  • D. R. Gill
  • M. P. Gallagher


Bacterial binding protein-dependent transport systems are the best characterized members of a superfamily of transporters which are structurally, functionally, and evolutionary related to each other. These transporters are not only found in bacteria but also in yeasts, plants, and animals including man, and include both import and export systems. Although any single system is relatively specific, different systems handle very different substrates which can be inorganic ions, amino acids, sugars, large polysaccharides, or even proteins. Some are of considerable medical importance, including Mdr, the protein responsible for multidrug resistance in human tumors, and the product of the cystic fibrosis locus. In this article we review the current state of knowledge on the structure and function of the protein components of these transporters, the mechanism by which transport is mediated, and the role of ATP in the transport process.

Key Words

ATP periplasm binding protein cystic fibrosis multidrug resistance P-glycoprotein import export transport membrane protein 


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Copyright information

© Plenum Publishing Corporation 1990

Authors and Affiliations

  • C. F. Higgins
    • 1
  • S. C. Hyde
    • 1
  • M. M. Mimmack
    • 1
  • U. Gileadi
    • 1
  • D. R. Gill
    • 1
  • M. P. Gallagher
    • 2
  1. 1.ICRF Laboratories, Institute of Molecular MedicineUniversity of Oxford, John Radcliffe HospitalOxfordEngland
  2. 2.Department of MicrobiologyUniversity of EdinburghEdinburghScotland

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