Journal of Bioenergetics and Biomembranes

, Volume 22, Issue 2, pp 157–179

Molecular mechanisms of calcium-induced membrane fusion

  • Demetrios Papahadjopoulos
  • Shlomo Nir
  • Nejat Düzgünes

DOI: 10.1007/BF00762944

Cite this article as:
Papahadjopoulos, D., Nir, S. & Düzgünes, N. J Bioenerg Biomembr (1990) 22: 157. doi:10.1007/BF00762944


We have reviewed studies on calcium-induced fusion of lipid bilayer membranes and the role of synexin and other calcium-binding proteins (annexins) in membrane fusion. We have also discussed the roles of other cations, lipid phase transitions, long chain fatty acids and other fusogenic molecules. Finally, we have presented a simple molecular model for the mechanism of lipid membrane fusion, consistent with the experimental evidence and incorporating various elements proposed previously.

Key Words

Liposomes annexins membrane-fusion model-membranes calcium lipid-bilayer calcium-binding-proteins 

Copyright information

© Plenum Publishing Corporation 1990

Authors and Affiliations

  • Demetrios Papahadjopoulos
    • 1
    • 2
  • Shlomo Nir
    • 4
  • Nejat Düzgünes
    • 1
    • 3
  1. 1.Cancer Research InstituteUniversity of CaliforniaSan Francisco
  2. 2.Department of PharmacologyUniversity of CaliforniaSan Francisco
  3. 3.Department of Pharmaceutical ChemistryUniversity of CaliforniaSan Francisco
  4. 4.The Seagram Center, Faculty of AgricultureHebrew University of JerusalemRehovotIsrael

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