Journal of Bioenergetics and Biomembranes

, Volume 19, Issue 3, pp 297–303

Action of cyclosporine on mitochondrial calcium fluxes

  • N. Fournier
  • G. Ducet
  • A. Crevat
Research Articles

Abstract

Cyclosporine (Cys A) is a potent immunosuppressor used to reduce rejection in transplantation surgery. We studied its action upon mitochondrial functions: oxidative phosphorylation and Ca2+ movements through mitochondrial membrane. We show that Cys A exhibits an inhibitory effect upon mitochondrial respiration. This result is in good agreement with previous works and may be correlated with Cys A toxicity. The action of cyclosporine on calcium fluxes is more pronounced. Indeed it blocks mitochondrial calcium efflux and allows mitochondria to accumulate a large amount of calcium. If this effect occurs in the cell, it would induce a Ca2+ decrease in cytosol. This action might be correlated with the inhibitory effect of Cys A upon the mitogenic stimulation of T lymphocytes.

Key Words

Cyclosporine calcium mitochondria 

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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • N. Fournier
    • 1
  • G. Ducet
    • 2
  • A. Crevat
    • 1
  1. 1.Laboratoire de BiophysiqueFaculté de PharmacieMarseilleFrance
  2. 2.Laboratoire de Physiologie CellulaireFaculte des SciencesMarseilleFrance
  3. 3.Laboratoire de BiophysiqueFaculté de PharmacieMarseille Cedex 5France

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