Cytotechnology

, Volume 11, Supplement 1, pp S91–S93

Cell adhesion molecules duringXenopus myogenesis

  • Giovanni Levi
Session 4 Adhesion Molecules Invited Lectures

Abstract

Muscle development is characterized by several cell-recognition events such as the fusion of primary and secondary myoblasts and synaptogenesis. Cell surface adhesion receptors are probably playing an important role in determining the correct evolution of these processes. In this paper we examine the expression of three cell adhesion molecules, N-CAM, N-cadherin and EP-cadherin, duringXenopus larval muscle development. Their differential distribution suggests a specific role for each of these molecules during myogenesis. N-CAM might control the fusion of primary myoblasts as its expression is particularly high in these cells and decreases sharply in myotubes. EP-cadherin is present both in differentiated myotubes and myoblasts and could be involved in secondary myoblast fusion. While N-cadherin appears only much later during muscle differentiation.

References

  1. Dickson, G., Peck, D., Moore, S.E., Barton, C.H. and Walsh, F.S. (1990). ‘Enhanced myogenesis in NCAM-transfected myoblasts’, Nature 344, 348–351.Google Scholar
  2. Knudsen, K.A., McElwee, S.A. and Myers, L. (1990a). ‘A role for the neural cell adhesion molecule, N-CAM, in myoblast interaction during myogenesis’, Dev. Biol. 138, 159–168.Google Scholar
  3. Knudsen, K.A., Myers, L. and McElwee, S.A. (1990b). ‘A role for the Ca+2-dependent cell adhesion molecule, N-cadherin, in myoblast interaction during myogenesis’, Exp. Cell Res. 188, 175–184.Google Scholar
  4. Levi, G., Broders, F., Dunon, D., Edelman, G.M. and Thiery, J.P. (1990). ‘Thyroxine-dependent modulations of the expression of the neural cell adhesion molecule N-CAM during Xenopus laevis metamorphosis’, Development 109, 681–692.Google Scholar
  5. Levi, G., Ginsberg, D., Girault, J.-M., Sabanay, I., Thiery, J.P. and Geiger, B. (1991). ‘EP-cadherin in muscles and epithelia of Xenopus laevis embryos’, Development 113, 1335–1344.Google Scholar
  6. Rosen, G.D., Sanes, J.R., LaChance, R., Cunningham, J.M., Roman, J. and Dean, D.C. (1992). ‘Roles for the integrin VLA-4 and its counter receptor VCAM-1 in myogenesis’, Cell 69, 1107–1119.Google Scholar
  7. Simonneau, L., Broders, F. and Thiery, J.P. (1992). ‘Localization of N-cadherin transcripts in Xenopus laevis from early tailbud to tadpole”, Developmental Dynamics 193, (in press).Google Scholar
  8. Wheelock, M.J. and Knudsen, K.K. (1991). ‘N-cadherin-associated proteins in chicken muscle’. Differentiation 46, 35–42.Google Scholar
  9. Wilkinson, D.G., Bailes, J.A., Champion, J.E. and McMahon A.P. (1987). ‘A molecular analysis of mouse development from 8 to 10 days post coitum detects changes in embryonic globin expression’, Development 99, 493–500.Google Scholar

Copyright information

© Kluwer Academic Publishers 1993

Authors and Affiliations

  • Giovanni Levi
    • 1
    • 2
  1. 1.Department of Cell DifferentiationI.S.T.GENOVA(Italy)
  2. 2.Ecole Normale SuperieureParisFrance

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