Archives of Dermatological Research

, Volume 257, Issue 3, pp 233–237 | Cite as

The effects of prostaglandins E1 and F2α on epidermal growth

  • C. B. Bentley-Phillips
  • H. Paulli-Jørgensen
  • R. Marks
Article
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Summary

The effects of prostaglandins E1 and F2α (PGE1 and PGF2a) on the growth of guinea pig epidermis have been studied in vivo. The prostaglandins were injected intradermally into guinea pigs, and tritiated thymidine was injected intraperitoneally prior to sacrifice. The autoradiographic labelling indices (L.I.) were assessed and a significant increase was found 4 b after injection of PGE1-an effect which lasted for up to 72 h. PGF2a injections had no significant effect on the L.I.

Keywords

Public Health Prostaglandin PGE1 Thymidin Tritium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

Der Effekt der Prostaglandine E1 und F2α auf das Wachstum der Epidermis von Meerschweinchen wurde in vivo untersucht. Die Prostaglandine wurden intradermal injiziert; mit Tritium markiertes Thymidin wurde intraperidonial vor dem Töten der Tiere injiziert. Die autoradiographischen Daten (labelling indices) wurden bestimmt. Ein signifikanter Anstieg wurde 4 h nach der Injektion von PGE1 ermittelt, ein Effekt der mindestens 72 h anhielt. PGF2a-Injektionen hatten keinen Einfluß auf den L.I.

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • C. B. Bentley-Phillips
    • 1
  • H. Paulli-Jørgensen
    • 1
  • R. Marks
    • 1
  1. 1.Department of MedicineWelsh National School of MedicineCardiffGreat Britain

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