Glycoconjugate Journal

, Volume 11, Issue 5, pp 414–417 | Cite as

PA-I and PA-II lectin interactions with the ABO(H) and P blood group glycosphingolipid antigens may contribute to the broad spectrum adherence ofPseudomonas aeruginosa to human tissues in secondary infections

  • Nechama Gilboa-Garber
  • Dvora Sudakevitz
  • Masha Sheffi
  • Ruth Sela
  • Cyril Levene
Lectin Papers


Pseudomonas aeruginosa may cause serious infections in most human tissues/organs. Its adherence to them is mediated by a battery of adhesins including the PA-I and PA-II lectins, which are produced in this bacterium in high quantities. PA-I binds to thed-galactose of the erythrocyte glycosphingolipids exhibiting highest affinities for B and Pk (followed by P1) antigens, while PA-II preferentially binds to thel-fucose of H, A and B antigens. IntactP. aeruginosa cells also exhibit a clear Pk and P1 over p preference. Such affinities for the most common human ABH and P system antigens may underlie the widespread tissue infectivity and pathogenicity of this bacterium.


Pseudomonas aeruginosa adherence lectin interactions glycosphingolipid antigens ABO blood group P system antigens 


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Copyright information

© Chapman & Hall 1994

Authors and Affiliations

  • Nechama Gilboa-Garber
    • 1
  • Dvora Sudakevitz
    • 1
  • Masha Sheffi
    • 1
  • Ruth Sela
    • 2
  • Cyril Levene
    • 2
  1. 1.Department of Life SciencesBar-Ilan UniversityRamat GanIsrael
  2. 2.The Blood Group Reference LaboratoryMinistry of HealthJerusalemIsrael

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