Glycoconjugate Journal

, Volume 11, Issue 5, pp 414–417 | Cite as

PA-I and PA-II lectin interactions with the ABO(H) and P blood group glycosphingolipid antigens may contribute to the broad spectrum adherence ofPseudomonas aeruginosa to human tissues in secondary infections

  • Nechama Gilboa-Garber
  • Dvora Sudakevitz
  • Masha Sheffi
  • Ruth Sela
  • Cyril Levene
Lectin Papers

Abstract

Pseudomonas aeruginosa may cause serious infections in most human tissues/organs. Its adherence to them is mediated by a battery of adhesins including the PA-I and PA-II lectins, which are produced in this bacterium in high quantities. PA-I binds to thed-galactose of the erythrocyte glycosphingolipids exhibiting highest affinities for B and Pk (followed by P1) antigens, while PA-II preferentially binds to thel-fucose of H, A and B antigens. IntactP. aeruginosa cells also exhibit a clear Pk and P1 over p preference. Such affinities for the most common human ABH and P system antigens may underlie the widespread tissue infectivity and pathogenicity of this bacterium.

Keywords

Pseudomonas aeruginosa adherence lectin interactions glycosphingolipid antigens ABO blood group P system antigens 

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References

  1. 1.
    Sabath LD (ed.) (1980) InPseudomonas aeruginosa, the Organism, Diseases it Causes, and their Treatment. Bern: Hans Huber Publishers.Google Scholar
  2. 2.
    Vasil ML (1986)J Pediatr 108:800–5.Google Scholar
  3. 3.
    Morihara K, Homma JY (1985) InBacterial Enzymes and Virulence (Holder IA, ed.) pp. 41–79. Boca Raton, FL: CRC.Google Scholar
  4. 4.
    Wood RE, Iglewski BH (1983)Rev Infect Dis 5:715–21.Google Scholar
  5. 5.
    Duguid JP, Old DC (1980) InBacterial Adherence (Beachey EH, ed.) pp. 187–217. London: Chapman & Hall Ltd.Google Scholar
  6. 6.
    Sharon N (1987)FEBS Lett 217:145–57.Google Scholar
  7. 7.
    Krivan HC, Roberts DD, Ginsburg V (1988)Proc Natl Acad Sci USA 85:6157–61.Google Scholar
  8. 8.
    Prince A (1992)Microbial Pathogenesis 13:251–60.Google Scholar
  9. 9.
    Gilboa-Garber N, Garber N (1992) InGlycoconjugates: Composition, Structure and Function (Allen HJ, Kisailus EC, eds) pp. 541–91. New York: Marcel Dekker Inc.Google Scholar
  10. 10.
    Gilboa-Garber N (1972)FEBS Lett 20:242–44.Google Scholar
  11. 11.
    Garber N, Sharon N, Shohet D, Lam JS, Doyle RJ (1985)Infect Immun 50:336–37.Google Scholar
  12. 12.
    Ramphal R, Sadoff JC, Pyle M, Silipigni JD (1984)Infect Immun 44:38–40.Google Scholar
  13. 13.
    Gilboa-Garber N (1982)Methods Enzymol 83:378–85.Google Scholar
  14. 14.
    Glick J, Garber N (1983)J Gen Microbiol 129:3085–90.Google Scholar
  15. 15.
    Race RR, Sanger R (1975)Blood Groups in Man, 6th edition. Oxford: Blackwell Scientific Publications.Google Scholar
  16. 16.
    Hakomori S (1986)Sci Amer 254:44–53.Google Scholar
  17. 17.
    Levene C, Gilboa-Garber N, Garber NC (1994) inLectin-Microorganism Interactions (Doyle RJ, Slifkin M, eds) pp. 327–93. New York: Marcel Dekker, Inc.Google Scholar
  18. 18.
    Anstee DJ, Holt PDJ, Pardoe GI (1973)Vox Sang 25:347–60.Google Scholar
  19. 19.
    Voak D, Todd GM, Pardoe GI (1974)Vox Sang 26:176–88.Google Scholar
  20. 20.
    Källenius G, Möllby R, Svenson SB, Winberg J, Lundblad A, Svensson S, Cedergren B (1980)FEMS Microbiol Lett 7:297–302.Google Scholar
  21. 21.
    Korhonen TK, Väisänen V, Saxén H, Hultberg H, Svenson SB (1982)Infect Immun 37:286–91.Google Scholar
  22. 22.
    Baker N, Hansson GC, Leffler H, Riise G, Svanborg-Eden C (1990)Infect Immun 58:2361–66.Google Scholar
  23. 23.
    Ramphal R, Carnoy C, Fievre S, Michalski JC, Houdret N, Lamblin G (1991)Infect Immun 59:700–4.Google Scholar
  24. 24.
    Baker NR, Minor V, Deal C, Shahrabadi MS, Simpson DA, Woods DE (1991)Infect Immun 59:2859–63.Google Scholar
  25. 25.
    Issitt PD (1985) InApplied Blood Group Serology, 3rd edition, pp. 203–18. Miami: Montgomery Scientific Publication.Google Scholar

Copyright information

© Chapman & Hall 1994

Authors and Affiliations

  • Nechama Gilboa-Garber
    • 1
  • Dvora Sudakevitz
    • 1
  • Masha Sheffi
    • 1
  • Ruth Sela
    • 2
  • Cyril Levene
    • 2
  1. 1.Department of Life SciencesBar-Ilan UniversityRamat GanIsrael
  2. 2.The Blood Group Reference LaboratoryMinistry of HealthJerusalemIsrael

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