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Virchows Archiv A

, Volume 415, Issue 1, pp 51–60 | Cite as

Neural crest origin of clear cell sarcoma of tendons and aponeuroses

Ultrastructural and enzyme cytochemical study of human and nude mouse-transplanted tumours
  • Yoshio Mii
  • Yoshizumi Miyauchi
  • Kanya Hohnoki
  • Hiroshi Maruyama
  • Masahiro Tsutsumi
  • Kayoko Dohmae
  • Susumu Tamai
  • Yoichi Konishi
  • Takahisa Yamanouchi
Article

Summary

In order to clarify the histogenesis of clear cell sarcoma of tendons and aponeuroses (CCS), two cases of human and one nude mouse-transplanted CCS line were studied using an ultrastructural and enzyme cytochemical approach. Most of the tumour cells obtained from the primary and transplanted CCS demonstrated melanosomes in various stages of development within the cytoplasm, whereas no melanosomes could be identified in the metastatic CCS. However, cholinesterase and tyrosinase activities could be demonstrated not only in the melanotic primary and transplanted CCS but also in the amelanotic metastatic CCS. The results therefore support the hypothesis that CCS is a soft tissue tumour derived from the neural crest.

Key words

Clear cell sarcoma Melanosomes Cytochemistry Electron microscopy Nude mouse 

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References

  1. Azumi N, Turner RR (1983) Clear cell sarcoma of tendons and aponeuroses: Electron microscopic findings suggesting Schwann cell differentiation. Hum Pathol 14:1084–1089Google Scholar
  2. Bearman RM, Noe J, Kempson RL (1975) Clear cell sarcoma with melanin pigment. Cancer 36:977–984Google Scholar
  3. Benson JD, Kraemer BB, Mackay B (1985) Malignant melanoma of soft parts: An ultrastructural study of four cases. Ultrastruct Pathol 8:57–70Google Scholar
  4. Boudreaux D, Waisman J (1978) Clear cell sarcoma with melanogenesis. Cancer 41:1387–1394Google Scholar
  5. Chung EB, Enzinger FM (1983) Malignant melanoma of soft parts. A reassessment of clear cell sarcoma. Am J Surg Pathol 7:405–413Google Scholar
  6. Dutra FM (1970) Clear cell sarcoma of tendons and aponeuroses: Three additional cases. Cancer 25:942–946Google Scholar
  7. Eckardt JJ, Pritchard DJ, Soule EH (1983) Clear cell sarcoma. Clinicopathologic study of 27 cases. Cancer 52:1482–1488Google Scholar
  8. Ekfors TO, Rantakokko V (1979) Clear cell sarcoma of tendons and aponeuroses: Malignant melanoma of soft tissue? Report of four cases. Pathol Res Pract 165:422–428Google Scholar
  9. Enzinger FM (1965) Clear-cell sarcoma of tendons and aponeuroses. Cancer 18:1163–1174Google Scholar
  10. Epstein AL, Martin AO, Kempson R (1984) Use of a newly established human cell line (SU-CCS-1) to demonstrate the relationship of clear cell sarcoma to malignant melanoma. Cancer Res 44:1265–1274Google Scholar
  11. Garcia RI, Szabo G (1979) Melanosomes in dermal Schwann cells of human and rodent skin. Arch Dermatol Res 264:83–87Google Scholar
  12. Hajdu SI, Shiu MH, Fortner JG (1977) Tenosynovial sarcoma. A clinicopathological study of 136 cases. Cancer 39:1201–1217Google Scholar
  13. Hoffman GJ, Carter D (1973) Clear cell sarcoma of tendons and aponeuroses with melanin. Arch Pathol 95:22–25Google Scholar
  14. Hunter JAA, Mottaz JH, Zelickson AS (1970) Melanogenesis: Ultrastructural histochemical observations on ultraviolet irradiated human melanocytes. J Invest Derm 54:213–221Google Scholar
  15. Hunter JAA, Paterson WD, Fairley D (1978) Human malignant melanoma. Melanosomal polymorphism and the ultrastructural DOPA reaction. Brit J Derm 98:381–390Google Scholar
  16. Karnovsky MJ (1964) The localization of cholinesterase activity in rat cardiac muscle by electron microscopy. J Cell Biol 23:217–232Google Scholar
  17. Kindblom LG, Lodding P, Angervall L (1983) Clear-cell sarcoma of tendons and aponeuroses. Virchows Arch Pathol Anat 401:109–128Google Scholar
  18. Kubo T (1969) Clear-cell sarcoma of patellar tendon studied by electron microscopy. Cancer 24:984–953Google Scholar
  19. Mackenzie DH (1974) Clear cell sarcoma of tendons and aponeuroses with melanin production. J Pathol 114:231–237Google Scholar
  20. Maul GG, Romsdahl MM (1970) Ultrastructural comparison of two human malignant cell lines. Cancer Res 30:2782–2790Google Scholar
  21. Mayahara H, Hirano H, Saito T, Ogawa K (1967) The new lead citrate method for the ultracytochemcial demonstration of activity of non-specific alkaline phosphatase (Orthophosphoric monoester phosphohydrase). Histochemie 11:88–96Google Scholar
  22. Mishima Y (1966) Cholinesterase and tyrosinase activity in malignant melanoma. Cancer 19:665–673Google Scholar
  23. Mukai M, Torikata C, Iri H, Mikata A, Kawai T, Hanaoka H, Yakumaru K, Kageyama K (1984) Histogenesis of clear cell sarcoma of tendons and aponeuroses. An electronmicroscopic, biochemical, enzyme histochemical, and immunohistochemical study. Am J Pathol 114:264–272Google Scholar
  24. Nakai T, Rappaport H (1963) A study of the histogenesis of experimental melanotic tumors resembling blue nevi: The evidence in support of their neurogenic origin. Am J Pathol 43:175–199Google Scholar
  25. Nakajima T, Watanabe S, Sato Y, Kameya T, Hirota T, Shimosato Y (1982a) An immunoperoxidase study of S-100 protein distribution in normal and neoplastic tissues. Am J Surg Pathol 6:715–727Google Scholar
  26. Nakajima T, Watnabe S, Sato Y, Kameya T, Shimosato Y, Ishihara K (1982b) Immunohistochemical demonstration of S-100 protein in malignant melanoma and pigment nevus, and its diagnostic application. Cancer 50:912–918Google Scholar
  27. Novikoff AB, Goldfischer S (1961) Nucleoside diphosphatase activity in the Golgi apparatus and its usefulness for cytologic studies. Proc Natl Acad Sci USA 47:802–810Google Scholar
  28. Novikoff AB, Albala A, Biempica L (1968) Ultrastructural and cytochemical observations on B-16 and Harding-Passay mouse melanomas. The origin of premelanosomes and compound melanosomes. J Histochem Cytochem 16:299–316Google Scholar
  29. Ohno T, Park P, Utsunomiya Y, Hirahata H, Inoue K (1986) Ultrastructural study of a clear cell sarcoma suggesting Schwannian differentiation. Ultrastruct Pathol 10:39–48Google Scholar
  30. Parker JB, Marcus PB, Martin JH (1980) Spinal melanotic clear-cell sarcoma: A light and electron microscopic study. Cancer 46:718–724Google Scholar
  31. Raynor AC, Vergas-cortes F, Alexander RW (1979) Clear-cell sarcoma with melanin pigment: A possible soft-tissue variant of malignant melanoma. Case report. J Bone Joint Surg 61-A:276–280Google Scholar
  32. Robinson JM, Karnovsky MJ (1983a) Ultrastructural localization of 5′-nucleotidase in guinea pig neutrophils based upon the use of cerium as capturing agent. J Histochem Cytochem 31:1190–1196Google Scholar
  33. Robinson JM, Karnovsky MJ (1983b) Ultrastructural localization of several phosphatases with cerium. J Histochem Cytochem 31:1197–1208Google Scholar
  34. Schmidt D, Mackay B (1982) Ultrastructure of human tendon sheath and synovium: Implications for tumor histogenesis. Ultrastruct Pathol 3:269–283Google Scholar
  35. Seiji M, Iwashita S (1965) Intracellular localization of tyrosinase and site of melanin formation in melanocytes. J Invest Derm 45:305–314Google Scholar
  36. Tokumitsu S, Tokumitsu K, Fishman WH (1981) Intracellular alkaline phosphatase activity in cultured human cancer cells. Histochemistry 73:1–13Google Scholar
  37. Tsuneyoshi M, Enjoji M, Kubo T (1978) Clear cell sarcoma of tendons and aponeuroses: A comparative study of 13 cases with a provisional subgrouping into the melanotic and synovial types. Cancer 42:243–252Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Yoshio Mii
    • 1
  • Yoshizumi Miyauchi
    • 1
  • Kanya Hohnoki
    • 1
  • Hiroshi Maruyama
    • 2
  • Masahiro Tsutsumi
    • 2
  • Kayoko Dohmae
    • 3
  • Susumu Tamai
    • 1
  • Yoichi Konishi
    • 2
  • Takahisa Yamanouchi
    • 3
  1. 1.Department of Orthopedic SurgeryNara Medical UniversityNaraJapan
  2. 2.Department of Oncological Pathology, Cancer CenterNara Medical UniversityNaraJapan
  3. 3.Quarters for Experimentally Infected Animals, Research Institute for Microbial DiseasesOsaka UniversityOsakaJapan

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