Virchows Archiv A

, Volume 413, Issue 5, pp 463–468

Cornelia de Lange syndrome associated with Wilms' tumour and infantile haemangioendothelioma of the liver: report of two autopsy cases

  • Masafumi Maruiwa
  • Yasuhiro Nakamura
  • Kazunori Motomura
  • Tatsuo Murakami
  • Masamichi Kojiro
  • Masahiro Kato
  • Minoru Morimatsu
  • Seiichi Fukuda
  • Takeo Hashimoto
Article

DOI: 10.1007/BF00716995

Cite this article as:
Maruiwa, M., Nakamura, Y., Motomura, K. et al. Vichows Archiv A Pathol Anat (1988) 413: 463. doi:10.1007/BF00716995

Summary

Two cases of Cornelia de Lange syndrome associated with infantile haemangioendothelioma of the liver and Wilms' tumour are reported. The patients showed the characteristic facies of the Cornelia de Lange syndrome, with synophrys, long curly eyelashes and small upturned nose, and physical features, including generalized hirsutism, monodactyly, syndactyly and clinodactyly. Post-mortem examination revealed annular pancreas, patency of the foramen ovale, duodenal atresia and evidence of cytomegalic infection. The cases are reported to document a possible association between malformations and neoplasms in this syndrome.

Key words

Cornelia de Lange syndrome Infantile haemangioendothelioma Wilms' tumour 

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Masafumi Maruiwa
    • 1
    • 2
  • Yasuhiro Nakamura
    • 1
    • 2
  • Kazunori Motomura
    • 1
    • 2
  • Tatsuo Murakami
    • 1
    • 2
  • Masamichi Kojiro
    • 1
    • 2
  • Masahiro Kato
    • 1
    • 2
  • Minoru Morimatsu
    • 1
    • 2
  • Seiichi Fukuda
    • 1
    • 2
  • Takeo Hashimoto
    • 1
    • 2
  1. 1.First and Second Departments of PathologyKurume University School of MedicineKurume-shi
  2. 2.Department of NeonatologySt. Mary's HospitalKurumeJapan

Personalised recommendations