Virchows Archiv A

, Volume 409, Issue 5, pp 725–738 | Cite as

A monoclonal antibody that detects myoepithelial cells in exocrine glands, basal cells in other epithelia and basal and suprabasal cells in certain hyperplastic tissues

  • J. Caselitz
  • B. Walther
  • J. Wustrow
  • G. Seifert
  • K. Weber
  • M. Osborn


Myoepithelial and luminal cells of human exocrine glands can be positively identified with two different monoclonal antibodies. Myoepithelial cells including those of the salivary gland, mammary gland and sweat gland are positively identified by an antibody CKB1. This antibody does not stain luminal cells, but stains the basal cell layer of certain human stratified epithelia and a few basal cells in simple epithelia. Thus myoepithelial cells and basal cells have certain common features. Luminal cells can be positively stained with the CK5 monoclonal keratin antibody specific for keratin polypeptide 18; this antibody does not stain myoepithelial cells. Of interest is that CKB1 also appears to stain basal and suprabasal cells in certain hyperplastic conditions.

Key words

Myoepithelial cells Monoclonal antibodies Keratin Salivary glands Mammary glands 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • J. Caselitz
    • 1
  • B. Walther
    • 1
  • J. Wustrow
    • 3
  • G. Seifert
    • 1
  • K. Weber
    • 2
  • M. Osborn
    • 2
  1. 1.Institute of PathologyUniversity of HamburgHamburg
  2. 2.Max Planck Institute for Biophysical ChemistryGöttingen
  3. 3.Ear-, Nose- and Throat ClinicsUniversity of KielKielGermany

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