Virchows Archiv A

, Volume 405, Issue 3, pp 333–340

Tumour-associated antigens in mammary and extramammary Paget's disease

  • Renato Mariani-Costantini
  • Salvatore Andreola
  • Franco Rilke


The immunoperoxidase technique was used to study the immunoreactivities of two murine monoclonal antibodies to carcinoma-associated antigens raised respectively against a human breast cancer line (MBrl) and an ovarian carcinoma (MOv2) and of a conventional anti-CEA serum in 20 cases of mammary Paget's disease of the nipple and in three cases of extramammary Paget's disease. Each of the immunoreagents stained Paget's cells in a high proportion of cases and failed to discriminate mammary from extramammary disease. The antigenic phenotypes of underlying in situ or infiltrating breast carcinomas corresponded to those of the associated Paget's disease of the nipple. The consistent immunoreactivity of eccrine and apocrine sweat glands and of normal mammary epithelia indicated an antigenic relationship between epithelia of adnexal derivation and Paget's cells.

Key words

Paget's disease Tumour-associated antigens Monoclonal antibodies Immunoperoxidase 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Renato Mariani-Costantini
    • 1
  • Salvatore Andreola
    • 2
  • Franco Rilke
    • 2
  1. 1.Division of Experimental Oncology AIstituto Naionale per to Studio e la Cura dei TumoriMilanItaly
  2. 2.Anatomical PathologyIstituto Naionale per to Studio e la Cura dei TumoriMilanItaly

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