Mycopathologia

, Volume 107, Issue 2–3, pp 131–137

Nitrate induces enzymes of the mannitol cycle and suppresses versicolorin synthesis inAspergillus parasiticus

  • Walter G. NiehausJr.
  • Weiping Jiang
Article

Abstract

Addition of sodium nitrate to growing cultures ofAspergillus parasiticus (ATCC 36537) induces the synthesis of enzymes involved in nitrate assimilation (NO3 reductase), of enzymes in the pentose pathway (glucose-6-phosphate dehydrogenase), and of enzymes in the mannitol cycle (mannitol- and mannitol-1-phosphate dehydrogenases). Addition of NO3 also causes a dose-dependent suppression of synthesis of the polyketide secondary metabolite, versicolorin A. We suggest that in the presence of NO3 plus peptone, the cytoplasmic NADPH/NADP ratio may be elevated, resulting in increased conversion of malonyl coenzyme A to fatty acid rather than to polyketide.

Key words

Aspergillus parasiticus ATCC 36537 enzyme induction mannitol dehydrogenase mannitol-1-phosphate dehydrogenase NADPH/NADP ratio nitrate reductase 

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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Walter G. NiehausJr.
    • 1
  • Weiping Jiang
    • 1
  1. 1.Biochemistry and NutritionVirginia Polytechnic Institute and State UniversityBlacksburgUSA

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