Acta Neuropathologica

, Volume 49, Issue 3, pp 187–191

Atypical senile dementia with widespread Lewy type inclusion in the cerebral cortex

  • S. Yagishita
  • Y. Itoh
  • N. Amano
  • T. Nakano
Original Works

Summary

An atypical case of senile dementia is reported which shows senile plaques, neurofibrillary tangles, granulovacuolar degeneration, and Hirano bodies and numerous Lewy bodies in the pigmented neurons of the brain stem, and Lewy-body-like inclusions in the cerebral cortex. The inclusions in the cerebral cortex had a strong resemblance to the Lewy bodies in the substantia nigra, though a few histochemical and ultrastructural differences were observed.

The pathological findings were unexpected since the parkinsonian syndrome was not recognized.

Key words

Atypical senile dementia Lewy body Cortical Lewy-like body 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Defendini R, Markesbery WR, Mastri AR, Duffy PE (1973) Hallervorden-Spatz disease and infantile neuroaxonal dystrophy. J Neurol Sci 20:7–23Google Scholar
  2. Duffy PE, Tennyson VM (1965) Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus coeruleus in Parkinson's diesease. J Neuropathol Exp Neurol 24:398–414Google Scholar
  3. Forno LS (1969) Concentric hyaline intraneural inclusions of Lewy type in the brains of elderly persons (50 incidental cases): Relationship to parkinsonism. J Am Geriatr Soc 17:557–575Google Scholar
  4. Forno LS, Norville RL (1976) Ultrastructure of Lewy bodies in the stellate ganglion. Acta Neuropathol (Berl) 34:183–197Google Scholar
  5. Forno LS, Barbour PJ, Norville RL (1978) Presenile dementia with Lewy bodies and neurofibrillary tangles. Arch Neurol 35:818–822Google Scholar
  6. Hirano A (1976) Progress in the pathology of motor neuron disease. In: Zimmerman HM (ed) Progress in neuropathology, vol 3. Grune and Stratton, New York, London, pp 181–215Google Scholar
  7. Ikeda K, Ikeda S, Yoshimura T, Kato H, Namba M (1978) Idiopathic parkinsonism with Lewy-type inclusions in cerebral cortex. A case report. Acta Neuropathol (Berl) 41:165–168Google Scholar
  8. Kaiya H (1974) Spino-olivo-ponto-cerebello-nigral atrophy with Lewy bpdies and binucleated nerve cells. A case report. Acta Neuropathol (Berl) 30:263–269Google Scholar
  9. Kosaka K, Oyanagi S, Matsushita M, Hori A (1976) Presenile dementia with Alzheimer- Pick- and Lewy body changes. Acta Neuropathol (Berl) 36:221–233Google Scholar
  10. Kosaka K (1978) Lewy bodies in cerebral cortex. Report of three cases. Acta Neuropathol (Berl) 42:127–134Google Scholar
  11. Kosaka K, Mehraein P (1979) Dementia-parkinsonism syndrome with numerous Lewy bodies and senile plaques in cerebral cortex. Arch Psychiatr Nervenkr 226:241–250Google Scholar
  12. Ogasawara N, Takamatsu K, Monma Y, Itoh T (1978) Presenile Demenz mit senilen Veränderungen, argentophilen Kugeln und Lewy-Körperchen. J Neuropathol Exp Neurol 47:667Google Scholar
  13. Ohama E, Ikuta F (1976) Parkinson's disease. Distribution of Lewy bodies and monoamine neuron system. Acta Neuropathol (Berl) 34:311–319Google Scholar
  14. Okazaki H, Lipkin LE, Aronson SM (1961) Diffuse intracytoplasmic ganglionic inclusions (Lewy type) associated with progressive dementia and quadriparesis in flexion. J Neuropathol Exp Neurol 20:237–244Google Scholar
  15. Rosenblum WI, Ghatak NR (1979) Lewy bodies in the presence of Alzheimer's disease. Arch Neurol 36:170–171Google Scholar
  16. Turner B (1972) Pathology of paralysis agitans. Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 6. Elsevier, Amsterdam, pp 212–217Google Scholar
  17. Watanabe I, Vachel E, Tomita T (1977) Dense core vesicles around the Lewy bodies in incidental Parkinson's disease. An electron microscopic study. Acta Neuropathol (Berl) 39:173–175Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • S. Yagishita
    • 1
  • Y. Itoh
    • 1
  • N. Amano
    • 2
  • T. Nakano
    • 2
  1. 1.Division of PathologyKanagawa Rehabilitation CenterAtsugi-shi Kanagawa-kenJapan
  2. 2.Division of NeurologyKanagawa Rehabilitation CenterAtsugi-shi Kanagawa-kenJapan

Personalised recommendations