Acta Neuropathologica

, Volume 49, Issue 3, pp 187–191

Atypical senile dementia with widespread Lewy type inclusion in the cerebral cortex

  • S. Yagishita
  • Y. Itoh
  • N. Amano
  • T. Nakano
Original Works


An atypical case of senile dementia is reported which shows senile plaques, neurofibrillary tangles, granulovacuolar degeneration, and Hirano bodies and numerous Lewy bodies in the pigmented neurons of the brain stem, and Lewy-body-like inclusions in the cerebral cortex. The inclusions in the cerebral cortex had a strong resemblance to the Lewy bodies in the substantia nigra, though a few histochemical and ultrastructural differences were observed.

The pathological findings were unexpected since the parkinsonian syndrome was not recognized.

Key words

Atypical senile dementia Lewy body Cortical Lewy-like body 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • S. Yagishita
    • 1
  • Y. Itoh
    • 1
  • N. Amano
    • 2
  • T. Nakano
    • 2
  1. 1.Division of PathologyKanagawa Rehabilitation CenterAtsugi-shi Kanagawa-kenJapan
  2. 2.Division of NeurologyKanagawa Rehabilitation CenterAtsugi-shi Kanagawa-kenJapan

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