Subcutaneous and intramuscular implantation of sepiolite-collagen complexes

  • N. Olmo
  • J. Turnay
  • J. G. Gavilanes
  • M. A. Lizarbe
  • J. I. Herrera
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Abstract

The tissue response after subcutaneous or intramuscular implantation of sepiolite-collagen complexes has been studied. These implants form a continuous three-dimensional matrix, showing a fibrous and rough surface topography. The host tissue response against the collagen-sepiolite complexes is a foreign-body reaction, focally intense, with abundant giant cells, typical of resorbable biomaterials. Sepiolite-collagen complex (SC) appears to be well tolerated and almost entirely resorbed within most of the experimental lesions. Sepiolite-collagen complex cross-linked with glutaraldehyde (SCG) demonstrates a significantly greater resistance to biodegradation than the non-cross-linked product. The anti-bovine collagen antibody levels in the sera of implanted rats were studied. The subcutaneous implantation of SC complexes induces a low immunological reaction, while it is almost negligible for the SCG ones.

Keywords

Biodegradation Glutaraldehyde Giant Cell Surface Topography Antibody Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Chapman & Hall 1992

Authors and Affiliations

  • N. Olmo
    • 1
  • J. Turnay
    • 1
  • J. G. Gavilanes
    • 1
  • M. A. Lizarbe
    • 1
  • J. I. Herrera
    • 2
  1. 1.Departamento de Bioquímica, Facultad de Ciencias QuímicasUniversidad ComplutenseMadridSpain
  2. 2.Departamento de Medicina y Cirugia Bucofacial, Facultad de OdontologiaUniversidad Complutense de MadridMadridSpain

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