Virchows Archiv A

, Volume 406, Issue 3, pp 373–380

Multiple paraganglioneuromas

  • Kenji Kawaguchi
  • Touichiro Takizawa
  • Morio Koike
  • Ikuo Tabata
  • Narihide Goseki
Case Report

DOI: 10.1007/BF00704306

Cite this article as:
Kawaguchi, K., Takizawa, T., Koike, M. et al. Vichows Archiv A Pathol Anat (1985) 406: 373. doi:10.1007/BF00704306

Summary

We report multiple paraganglioneuromas which occurred in a 40-year-old-man. Thirty-two tumours with similar histological appearance have been reported previously and most of them showed a striking predilection to occur in the second portion of the duodenum. In this case, three masses were detected; one was located in the periampullary region of duodenum with a polypoid appearance, the others were well defined masses in peri-pancreatic tissue adjacent to large vessels. Histology revealed two cellular components, epithelioid cells with NSE immunoreactivity and S-100 protein containing spindle-shaped cells. Moreover, on electron microscopical examination, three different epithelioid cell types were seen. Type I was a figure differentiating to ganglion cells, type II to paraganglion cells, type III was a hybrid form of ganglion and paraganglion cells. Paraganglioneuroma revealed the histopathology of ganglioneuroma, paraganglioma and also a mixed appearance. In this respect the tumour may be considered to originate in undifferentiated neural crest cells and develop organoid differentiation.

Key words

Paraganglioneuroma Paraganglioma Ganglioneuroma Gangliocytic paraganglioma Hybrid cell 

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Kenji Kawaguchi
    • 1
  • Touichiro Takizawa
    • 1
  • Morio Koike
    • 1
  • Ikuo Tabata
    • 2
  • Narihide Goseki
    • 3
  1. 1.Department of PathologyTokyo Metropolitan Komagome HospitalTokyoJapan
  2. 2.Department of MedicineTokyo Metropolitan Komagome HospitalTokyoJapan
  3. 3.Department of SurgeryTokyo Metropolitan Komagome HospitalTokyoJapan

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