Chemical reactions of calcium phosphate implants after implantationin vivo

  • F. C. M. Driessens
  • M. M. A. Ramselaar
  • H. G. Schaeken
  • A. L. H. Stols
  • P. J. Van Mullem
  • J. R. De Wijn


Sintered microporous cylinders of hydroxyapatite (OHA), tertiary calcium phosphate (β-TCP and rhenanite (CaNaPO4) were implanted in the bone of the forehead of the domestic pig (Sus scrofa). Implants together with the surrounding bone were retrieved after 6 and 12 weeks. X-ray diffraction showed that OHA and β-TCP maintain their crystal structure upon implantation. However, rhenanite is transformed completely into an apatite within 6 weeks. This apatite later incorporates sodium and carbonate. Both β-TCP and rhenanite implants showed some resorption but were otherwise covered with new bone. Electron microprobe analysis showed that the mineral at the interface had a Ca/P ratio characteristic of new bone. At a certain distance from the interface lower Ca/P ratios were found, characteristic of precursor phases of bone mineral. This suggests that the deposition of new bone starts, at least partially, from the surface of the implant. Therefore, β-TCP as well as rhenanite may be called an osteoconductive biomaterial.


Polymer Crystal Structure Bone Mineral Apatite Hydroxyapatite 
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  1. 1.
    F. C. M. DRIESSENS, “Bioceramics of calcium phosphate”, edited by K. de Groot (CRC Press, Boca Raton, Florida, 1983) p. 1.Google Scholar
  2. 2.
    F. C. M. DRIESSENS and R. M. H. VERBEECK, “Biominerals” (CRC Press, Boca Raton, Florida, 1989).Google Scholar
  3. 3.
    T. D. DRISKELL, C. R. HASSLER, V. J. TENNERY, L. R. McCOY and W. J. CLARKE,IADR Abstr. (1973) 259Google Scholar
  4. 4.
    M. JARCHO,Clin. Orthopaed. 157 (1981) 259Google Scholar
  5. 5.
    M. L. RABALAIS, R. A. YUKNA and E. T. MAYER,J. Periodont. 52 (1981) 680.Google Scholar
  6. 6.
    H. G. JACOBS, H. G. LUHR, A. KRAUSE and H. ÜBERALL,Dtsch. Z. Mund Kiefer Gesichts Chir. 8 (1984) 38.Google Scholar
  7. 7.
    A. KRAUSE, H. WEHRBEIN, H. G. JACOBS and S. MORICH, ibid.10 (1986) 108.Google Scholar
  8. 8.
    C. P. A. T. KLEIN, P. PATKA and W. DEN HOLLANDER,Biomaterials 10 (1989) 59.Google Scholar
  9. 9.
    K. DE GROOT,Zahnärztl Mitteil. 75 (1985) 1938.Google Scholar
  10. 10.
    W. RENOOIJ, H. A. HOOGENDOORN, H. A. VISSER, R. H. F. LENTFERINK, M. G. J. SCHMITZ, H. VAN IEPEREN, S. J. OLDENBURG, W. M. JANSEN, L. M. A. AKKERMANS and P. WITTEBOL,Clin. Orthopaed. Relat. Res. 197 (1985) 272.Google Scholar
  11. 11.
    M. WINTER, P. GRISS, K. DE GROOT, H. TAGAI, G. HEIMKE, H. J. A. VAN DIJK and K. SAWAI,Biomaterials 2 (1981) 159.Google Scholar
  12. 12.
    H. NEWESLY,Zahn Mund Kieferheilk. 72 (1984) 230.Google Scholar
  13. 13.
    F. C. M. DRIESSENS,Ann. N Y Acad. Sci. 523 (1988) 131.Google Scholar
  14. 14.
    F. C. M. DRIESSENS and R. M. H. VERBEECK, in “Implant materials in biofunction”, edited by C. de Putter, G. L. de Lange, K. de Groot and A. J. C. Lee (Elsevier, Amsterdam, 1988) p. 105.Google Scholar
  15. 15.
    F. C. M. DRIESSENS, in First European Ceramic Society Conference, Maastricht, 1989, BI p. 15.Google Scholar
  16. 16.
    C. P. A. T. KLEIN, A. A. DRIESSEN and K. DE GROOT,Biomaterials 5 (1984) 157.Google Scholar
  17. 17.
    E. FISCHER-BRANDIES, E. DIELERT, G. BAUER, F. H. FEDER, G. REIDEL and S. MÖLLENSTADT,Dtsch. Zahnärztl. Z. 44 (1989) 436.Google Scholar
  18. 18.
    J. W. FERRARO, Plast. Reconstr. Surg.63 (1979) 634.Google Scholar
  19. 19.
    H. U. CAMERON, I. MAENEB and R. M. PILLIAR,J. Biomed. Mater. Res. 11 (1977) 179.Google Scholar
  20. 20.
    R. M. H. VERBEECK, H. J. M. HEIJLIGERS, F. C. M. DRIESSENS and H. G. SCHAEKEN,Z. Anorg. Allg. Chem. 466 (1980) 76.Google Scholar
  21. 21.
    R. M. H. VERBEECK, H. P. THUN and F. C. M. DRIESSENS,Z. Phys. Chem. (Neue Folge) 119 (1980) 79.Google Scholar
  22. 22.
    I. ORLY, M. GREGOIRE, J. MENANTEAU, M. HEUGHEBAERT and B. KEREBEL,Calcif. Tiss. Int. 45 (1989) 20.Google Scholar
  23. 23.
    T. M. GREGORY, E. C. MORENO, J. M. PATEL and W. E. BROWN,J. Res. Natn. Bureau Standards USA 78A (1974) 667.Google Scholar
  24. 24.
    R. M. H. VERBEECK, P. A. M. DE BRUIJNE, F. C. M. DRIESSENS, R. A. TERPSTRA and F. VERBEEK,Bull. Soc. Chim. Belg. 95 (1986) 455.Google Scholar
  25. 25.
    M. M. A. RAMSELAAR, P. J. VAN MULLEM, J. R. DE WIJN, F. C. M. DRIESSENS and W. KALK,J. Mater. Sci. Mater. Med. 2 (1991) 63.Google Scholar
  26. 26.
    F. C. M. DRIESSENS, R. A. TERPSTRA, P. BENNEMA, J. H. M. WÖLTGENS and R. M. H. VERBEECK,Z. Naturforsch. 42c (1987) 916.Google Scholar
  27. 27.
    F. C. M. DRIESSENS, J. M. P. M. BORGGREVEN and R. M. H. VERBEECK,Bul. Soc. Chim. Belg. 96 (1987) 173.Google Scholar
  28. 28.
    F. C. M. DRIESSENS and R. M. H. VERBEECK,Z. Naturforsch. 41c (1986) 468.Google Scholar
  29. 29.
    H. G. SCHAEKEN, F. C. M. DRIESSENS and R. M. H. VERBEECK,Z. Anorg. Allg. Chem. 505 (1983) 48.Google Scholar
  30. 30.
    G. GUILLEMIN, J. L. PATAT, A. MEUNIER and P. CHRISTEL, in 8th European Conference on Biomaterials, Heidelberg, September 1989, Paper C2–5.Google Scholar
  31. 31.
    H. OONISHI, H. AOKI, E. TSUJI and T. MIZUKOSHI, in 2nd International Symposium on Ceramics in Medicine (Bioceramics), Heidelberg, 1989, Paper V-6.Google Scholar
  32. 32.
    F. C. M. DRIESSENS and R. M. H. VERBEECK, “Biominerals” (CRC Press, Boca Raton, Florida, 1990).Google Scholar

Copyright information

© Chapman & Hall 1992

Authors and Affiliations

  • F. C. M. Driessens
    • 1
    • 2
  • M. M. A. Ramselaar
    • 1
    • 2
  • H. G. Schaeken
    • 1
    • 2
  • A. L. H. Stols
    • 2
  • P. J. Van Mullem
    • 1
  • J. R. De Wijn
    • 3
  1. 1.Departments of Oral Function and Prosthetic DentistryOral Histology Dental SchoolThe Netherlands
  2. 2.Cell Biology and Histology, Medical SchoolUniversity of NijmegenThe Netherlands
  3. 3.Department of BiomaterialsState University of LeidenThe Netherlands

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