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Chemical reactions of calcium phosphate implants after implantationin vivo

  • F. C. M. Driessens
  • M. M. A. Ramselaar
  • H. G. Schaeken
  • A. L. H. Stols
  • P. J. Van Mullem
  • J. R. De Wijn
Papers

Abstract

Sintered microporous cylinders of hydroxyapatite (OHA), tertiary calcium phosphate (β-TCP and rhenanite (CaNaPO4) were implanted in the bone of the forehead of the domestic pig (Sus scrofa). Implants together with the surrounding bone were retrieved after 6 and 12 weeks. X-ray diffraction showed that OHA and β-TCP maintain their crystal structure upon implantation. However, rhenanite is transformed completely into an apatite within 6 weeks. This apatite later incorporates sodium and carbonate. Both β-TCP and rhenanite implants showed some resorption but were otherwise covered with new bone. Electron microprobe analysis showed that the mineral at the interface had a Ca/P ratio characteristic of new bone. At a certain distance from the interface lower Ca/P ratios were found, characteristic of precursor phases of bone mineral. This suggests that the deposition of new bone starts, at least partially, from the surface of the implant. Therefore, β-TCP as well as rhenanite may be called an osteoconductive biomaterial.

Keywords

Polymer Crystal Structure Bone Mineral Apatite Hydroxyapatite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Chapman & Hall 1992

Authors and Affiliations

  • F. C. M. Driessens
    • 1
    • 2
  • M. M. A. Ramselaar
    • 1
    • 2
  • H. G. Schaeken
    • 1
    • 2
  • A. L. H. Stols
    • 2
  • P. J. Van Mullem
    • 1
  • J. R. De Wijn
    • 3
  1. 1.Departments of Oral Function and Prosthetic DentistryOral Histology Dental SchoolThe Netherlands
  2. 2.Cell Biology and Histology, Medical SchoolUniversity of NijmegenThe Netherlands
  3. 3.Department of BiomaterialsState University of LeidenThe Netherlands

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