Journal of Biological Physics

, Volume 20, Issue 1–4, pp 283–287 | Cite as

Phosphoryl amino acids: Common origin for nucleic acids and protein

  • Yu-Fen Zhao
  • Pei-sheng Cao
Section 9. Origin And Structure Of The Cell: Chemical Aspects


A series of compounds (DAP-AA) composed of an amino acid (AA) and a dialkyl phosphoryl group (DAP) is the basic elements of life chemistry. Self-catalysis of DAP-AA gives the self-assembly oligopeptides, even in aqueous medium at 38°C. The oligo-nucleotides could also be assembled from nucleosides' phosphorylation by DAP-AA. DAP-AA acts as the energy source as well as the phosphoryl donor for the synthesis of nuclic Acids and protein. A general expression for the self assembly system is proposed.

Key words

basic element of life chemistry model expression phosphoryl amino acids Origin of life 


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Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Yu-Fen Zhao
    • 1
  • Pei-sheng Cao
    • 1
  1. 1.Department of Chemistry, Laboratory of Bio-organic Phosphorus ChemistryTsinghua UniversityBeijingPeople's Republic of China

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