Acta Neuropathologica

, Volume 36, Issue 4, pp 387–391

Alterations in the hippocampus of aged mice

  • C. H. Lamar
  • E. J. Hinsman
  • C. K. Henrikson
Short Original Communications


The hippocampus of C57B1/6 mice was examined histologically and electron microscopically. Male and female mice at 3 and 8 months of age and female mice at 16 months of age were studied. PAS positive foci, containing particles 1–2 μ in diameter, were observed in the hippocampal region of 8 and 16 month old mice. These particles were diastase sensitive. Electron microscopically, in similar mice, a vacuolating change was observed in the cytoplasm of perithelial cells (pericytes) in the same area.

Key words

Aging Hippocampus Pericytes-mice 


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • C. H. Lamar
    • 1
  • E. J. Hinsman
    • 1
  • C. K. Henrikson
    • 1
  1. 1.School of Veterinary MedicinePurdue UniversityWest LafayetteUSA

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