Acta Neuropathologica

, Volume 36, Issue 4, pp 387–391

Alterations in the hippocampus of aged mice

  • C. H. Lamar
  • E. J. Hinsman
  • C. K. Henrikson
Short Original Communications

Summary

The hippocampus of C57B1/6 mice was examined histologically and electron microscopically. Male and female mice at 3 and 8 months of age and female mice at 16 months of age were studied. PAS positive foci, containing particles 1–2 μ in diameter, were observed in the hippocampal region of 8 and 16 month old mice. These particles were diastase sensitive. Electron microscopically, in similar mice, a vacuolating change was observed in the cytoplasm of perithelial cells (pericytes) in the same area.

Key words

Aging Hippocampus Pericytes-mice 

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References

  1. Adelman, R. C.: Impaired hormonal regulation of enzyme activity during aging. Fed. Proc.34, 179–182 (1975)Google Scholar
  2. Allen, F. P., Terry, R. D., Zellivger, H.: Electron microscopy of two cerebral biopsies in gargoylism. J. Neuropath. exp. Neurol.24, 304–317 (1965)Google Scholar
  3. Andrew, W.: The nervous system. In: The anatomy of aging in man and animals, pp. 218–237. New York: Greene and Stratton 1971Google Scholar
  4. Franks, L. M.: Cellular aspects of aging. Exp. Geront.5, 281–289 (1970)Google Scholar
  5. Hasan, M., Glees, P.: Ultrastructural age changes in hippocampal neurons, synapses, and neuroglia. Exp. Geront.8, 75–83 (1965)Google Scholar
  6. Herman, R. L.: Aging. In: Handbook of Neurochemistry (ed. A. Lajatha), Vol. 5, Part B, pp. 481–487. New York: Plenum Press 1971Google Scholar
  7. Kerenyi, T., Haranghy, L., Huttner, L.: Investigations on experimentally produced agepigment in the nervous system. Exp. Geront.3, 155–158 (1968)Google Scholar
  8. McGeer, E. G., Fibriger, H. C., McGeer, P. L., Wickson, V.: Aging and brain enzymes. Exp. Geront.6, 391–396 (1971)Google Scholar
  9. Robinson, D. S.: Changes in monoamine oxidase and monoamines with human development and aging. Fed. Proc.34, 103–107 (1975)Google Scholar
  10. Schochet, S. S., Jr., McCormick, N. F.: Ultrastructure of Hirano bodies. Acta neuropath. (Berl.)21, 50–60 (1972)Google Scholar
  11. Thompson, S. W.: Selected. histochemical and histopathological methods, pp. 1274 to 1276. Springfield, Ill.: Ch. C. Thomas 1966Google Scholar
  12. Toth, S. E.: The origin of lipofuscin age pigments. Exp. Geront.3, 19–30 (1968)Google Scholar
  13. Wisniewski, H. M., Johnson, A. B., Raine, C. S., Kay, W. J., Terry, R. D.: Senile plaques and cerebral amyloidosis in aged dogs: A histochemical and ultrastructural study. Lab. Invest.23, 287–296 (1970)Google Scholar
  14. Wisniewski, H. M., Terry, R. D.: Morphology of the aging brain, human, and animal. Progr. Brain Res.40, 166–186 (1973)Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • C. H. Lamar
    • 1
  • E. J. Hinsman
    • 1
  • C. K. Henrikson
    • 1
  1. 1.School of Veterinary MedicinePurdue UniversityWest LafayetteUSA

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