Acta Neuropathologica

, Volume 61, Issue 2, pp 157–160

Neuronal loss in the basal nucleus of meynert in progressive supranuclear palsy

  • F. Tagliavini
  • G. Pilleri
  • F. Gemignani
  • A. Lechi
Short Original Communications


A morphometric study of the basal nucleus of Meynert (bnM) has been performed in a 70-year-old man with a 4-year history of pathologically confirmed progressive supranuclear palsy (PSP). An important neuronal loss (52%) was demonstrated in the bnM. This finding has not been previously documented with morphometric methods in PSP, but the involvement of the bnM is well known in other related conditions, i.e., Parkinson's disease. Alzheimer's disease, and Parkinson-dementia complex of Guam. Our findings yield support to the view that the involvement of the bnM, a nucleus with complex connections with various subcortical structures and diffuse cholinergic projections on the neocortex, could play an important role in the physiopathogeny of subcortical dementia.

Key words

Progressive supranuclear palsy (PSP) Subcortical dementia Basal nucleus of Meynert Neuropathology 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • F. Tagliavini
    • 1
  • G. Pilleri
    • 1
  • F. Gemignani
    • 2
  • A. Lechi
    • 2
  1. 1.Brain Anatomy InstituteUniversity of BerneOstermundigenSwitzerland
  2. 2.Institute of NeurologyUniversity of ParmaParmaItaly

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