Acta Neuropathologica

, Volume 64, Issue 1, pp 85–88

Experimental transmission of human subacute spongiform encephalopathy to small rodents

IV. Positive transmission from a typical case of Gerstmann-Sträussler-Scheinker's disease
  • J. Tateishi
  • Y. Sato
  • H. Nagara
  • J. W. Boellaard
Short Original Communications

DOI: 10.1007/BF00695613

Cite this article as:
Tateishi, J., Sato, Y., Nagara, H. et al. Acta Neuropathol (1984) 64: 85. doi:10.1007/BF00695613
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Summary

Spongiform encephalopathy was transmitted to mice from a patient belonging to the “Sch” family with Gerstmann-Sträussler-Scheinker's disease (GSS). Incubation periods in the first passage were much shorter than those in mice infected with Creutzfeldt-Jakob disease. Clinical and pathologic findings of mice infected with both disease were almost identical. This is the first successful transmission from a typical GSS case without severe spongiform change which suggests the possible transmissible nature of this disorder.

Key words

Gerstmann-Sträussler-Scheinker's disease Spongiform encephalopathy Slow virus Experimental transmission Small rodents 

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • J. Tateishi
    • 1
  • Y. Sato
    • 1
  • H. Nagara
    • 1
  • J. W. Boellaard
    • 2
  1. 1.Dept. of Neuropathology, Institute of Neurology, Faculty of MedicineKyushu UniversityFukuokaJapan
  2. 2.Institut für Hirnforschung der Universität TübingenTübingenGermany

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