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Virchows Archiv A

, Volume 402, Issue 2, pp 185–193 | Cite as

DNA flow cytometric measurements in inflammatory and malignant human gastric lesions

  • Edgar Deinlein
  • Helmut Schmidt
  • Jürgen-Ferdinand Riemann
  • Rolf Gräßel-Pietrusky
  • Otto Paul Hornstein
Review

Summary

102 gastroscopically taken biopsy specimens which were normal (n=28) or showed superficial gastritis (n=18), chronic atrophic gastritis (n=18), gastric ulcers (n=19) and gastric carcinomas (n=19) were submitted to FCM analysis. Carcinomatous specimens were readily recognized by either ploidy abnormality or significantly raised S- and G2 + M values. Intestinal-type and diffuse carcinomas could not be distinguished by proliferation kinetics, however, diffuse carcinomas showed a higher rate of aneuploidy. Chronic atrophic gastritis and gastric ulcers, though significantly differing from both normal tissue and superficial gastritis, exhibited similar proliferation characteristics. In gastric ulcers, an S-phase proportion of more than 12% was correlated with histological detection of cellular atypias and a proliferative tendency.

Key words

Flow cytometry DNA content Gastric carcinomas Inflammatory gastric diseases Cell cycle stage distribution 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Edgar Deinlein
    • 1
  • Helmut Schmidt
    • 2
  • Jürgen-Ferdinand Riemann
    • 2
  • Rolf Gräßel-Pietrusky
    • 1
  • Otto Paul Hornstein
    • 1
  1. 1.Dermatologisches InstitutErlangenFederal Republic of Germany
  2. 2.Medizinisches Institut der Universität Erlangen-NürnbergErlangenFederal Republic of Germany

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