Virchows Archiv A

, Volume 405, Issue 1, pp 41–53 | Cite as

Palmar fibromatosis (Dupuytren's contracture)

Ultrastructural and enzyme histochemical studies of 43 cases
  • H. Iwasaki
  • H. Müller
  • H. J. Stutte
  • U. Brennscheidt


Forty three cases of palmar fibromatosis were studied by light and electron microscopy, enzyme histochemistry, and ultrastructural immunohistochemistry. By electron microscopy most of the cells composing the nodules in both the proliferative and the involutional stages were identical to myofibroblasts. The myofibroblasts in the involutional nodules often possessed microfilament aggregates probably representing contraction of micro(actin)fllaments in the cytoplasm. The proliferative nodules revealed small perivascular haemorrhages and haemosiderin deposits accompanied by accumulation of macrophages and some lymphocytes; these inflammatory cells possibly secrete a certain growth factor inducing proliferation of genetically abnormal fibroblasts and myofibroblasts. Diaminopeptidase IV was detected in myofibroblasts and fibroblasts by enzyme histochemistry and ultrastructural immunohistochemistry; the enzyme may play a role in the metabolism of intercellular substances. Some perivascular mesenchymal cells, interpreted as variants of myofibroblasts, had moderate activity of alkaline phosphatase.

Key words

Fibromatosis Dupuytren's contracture Myofibroblast Ultrastructure Histochemistry 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • H. Iwasaki
    • 1
  • H. Müller
    • 1
  • H. J. Stutte
    • 1
  • U. Brennscheidt
    • 1
  1. 1.Senckenbergisches Zentrum der Pathologie der Universität Frankfurt/M.Frankfurt/M. 70Federal Republic of Germany

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