Acta Neuropathologica

, Volume 49, Issue 1, pp 79–83 | Cite as

Thickening of the basement membrane of cortical capillaries in Alzheimer's disease

  • G. L. Mancardi
  • F. Perdelli
  • C. Rivano
  • A. Leonardi
  • O. Bugiani
Short Original Communications


Data concerning width and surface of the basement membrane of cortical capillaries in three patients with Alzheimer's disease five age-matched controls, have been submitted to statistical analysis to ascertain the role of the aging process upon thickening of the basement membrane itself. The analysis showed that there was a significant difference between patients with Alzheimer's disease and controls (P<0.01) as to both width and surface of the basement membrane, so suggesting that in these patients aging was not the only factor which thickening of the basement membrane of cortical capillaries was related to.

Key words

Alzheimer's disease Dementia Aging Cortical capillaries Basement membrane Electron microscopy 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • G. L. Mancardi
    • 1
  • F. Perdelli
    • 2
  • C. Rivano
    • 3
  • A. Leonardi
    • 1
  • O. Bugiani
    • 1
  1. 1.Clinica NeurologicaUniversità di GenovaGenovaItaly
  2. 2.Istituto di Statistica MedicaUniversità di GenovaGenovaItaly
  3. 3.Clinica NeurochirurgicaUniversità di GenovaGenovaItaly

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