Acta Neuropathologica

, Volume 61, Issue 3–4, pp 263–269 | Cite as

Marek's disease virus-induced transient paralysis: A comparison of lesions in susceptible and resistant lines of chickens

  • J. N. Kornegay
  • E. J. Gorgacz
  • M. A. Parker
  • J. R. Duncan
  • L. W. Schierman
Original Works

Summary

A study was conducted to determine the causative lesion of Marek's disease virus-induced transient paralysis. Brain histologic lesions were quantitated and compared in genetically resistant and susceptible inbred chickens. Comparisons were made 11 days post inoculation (PI) of virus when clinical signs were evident in susceptible birds and on day 17 PI when these signs had remitted. Clinically-affected birds from the susceptible line on day 11 PI had consistent evidence of neuropil vacuolation compatible with brain edema; two of these birds also had vasculitis. These lesions were absent in both clinically-recovered birds from this line evaluated on day 17 PI and genetically resistant birds studied on day 11 PI. Our findings suggest that the causative lesion of transient paralysis is vasogenic brain edema.

Key words

Marek's disease herpesvirus Transient paralysis Neuropil vacuolation Vasogenic brain edema 

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References

  1. Baker RN, Cancilla PA, Pollock PS, Frommes SP (1971) The movement of exogenous protein in experimental cerebral edema. An electron microscopic study after freeze-injury. J Neuropathol Exp Neurol 30:668–679Google Scholar
  2. Behan PO (1978) Post-infectious encephalomyelitis; some aetiological mechanisms. Postgrad Med J 54:755–759Google Scholar
  3. Blakemore WF (1969) The fate of escaped plasma protein after thermal necroris of the rat brain: An electron microscope study. J Neuropathol Exp Neurol 28:139–152Google Scholar
  4. Cho BR, Kenzy SG, Mathey WJ (1970) Histologic and microbiologic studies of chickens with transient paralysis. Avian Dis 14:587–598Google Scholar
  5. Churchill AE, Biggs PM (1967) Agent of Marek's disease in tissue culture. Nature (Lond) 215:528–530Google Scholar
  6. Jungherr EL (1969) The neuroanatomy of the domestic fowl. Avian Dis (Special Issue):1–126Google Scholar
  7. Kenzy SG, Cho BR, Kim Y (1973) Oncogenic Marek's disease herpesvirus in avian encephalitis (temporary paralysis). J Natl Cancer Inst 51:977–982Google Scholar
  8. Kornegay JN, Gorgacz EJ, Parker MA, Brown J, Schierman LW (1983) Marek's disease herpesvirus induced transient paralysis. Clinical and electrophysiologic findings in resistant and susceptible lines of chickens. Am J Vet Res (in press)Google Scholar
  9. Lee JC, Bakay L (1966) Ultrastructural changes in the edematous central nervous system. II. Cold-induced edema. Arch Neurol 14:26–49Google Scholar
  10. Marek J (1907) Multiple Nervenentzündung bei Hühnern. Dtsch Tierärztl Wochenschr 15:417–421Google Scholar
  11. Nazerian K, Solomon JJ, Witter RL, Burmester BR (1968) Studies on etiology of Marek's disease. II. Finding of a herpesvirus in cell culture. Proc Soc Exp Biol Med 127:177–182Google Scholar
  12. Oldstone MBA (1982) Immunopathologic disease of the central nervous system. In: Brockes J (ed) Neuroimmunology. Plenum Press, New York, pp 125–139Google Scholar
  13. Pappenheimer AM, Dunn LC, Cone V (1929) Studies on fowl paralysis (neurolymphomatosis gallinarum). I. Clinical features and pathology. J Exp Med 49:63–86Google Scholar
  14. Parker MA, Schierman LW (1983) Suppression of humoral immunity in chickens prevents transient paralysis caused by a herpesvirus. J Immunol 130:2000–2001Google Scholar
  15. Paterson PY (1982) Molecular and cellular determinants of neuroimmunologic inflammatory disease. Fed Proc 41:2569–2576Google Scholar
  16. Payne LN, Biggs PM (1967) Studies on Marek's disease. II. Pathogenesis. J Natl Cancer Inst 39:281–302Google Scholar
  17. Purcell DA, Taylor SM (1971) The histopathology of transient paralysis of the fowl. Br Vet J 127:313–317Google Scholar
  18. Redding RW, Braund KG (1978) Neurological examination. In: Hoerlein BF (ed) Canine neurology. Saunders, Philadelphia, pp 53–70Google Scholar
  19. Schierman LW, Fletcher OJ (1980) Genetic control of Marek's disease virus-induced transient paralysis: Association with the major histocompatibility complex. In: Biggs PM (ed) Resistance and immunity to Marek's disease. Commission of the European Communities, Brussels, pp 429–442Google Scholar
  20. Walker D, Grattan DAP (1968) A temporary paralytic syndrome of growing pullets. Vet Rec 82:43–47Google Scholar
  21. Wight PAL (1962a) Variations in peripheral nerve histopathology in fowl paralysis. J Comp Pathol Therap 72:40–48Google Scholar
  22. Wight PAL (1962b) The histopathology of the central nervous system in fowl paralysis. J Comp Pathol Therap 72:348–359Google Scholar
  23. Wight PAL (1968) The histopathology of transient paralysis of the domestic fowl. Vet Rec 82:749–755Google Scholar
  24. Willemart JP, Montlaur D, Verger M, Labrousse F (1967) La paralysie transitoire des poules domestiques. Rec Med Vet 143:253–261Google Scholar
  25. Zander DV (1959) Experiences with epidemic tremor control. In: Proceedings of 8th Annual Western Poultry Disease Conference, Davis, CA, pp 18–23Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • J. N. Kornegay
    • 1
  • E. J. Gorgacz
    • 1
  • M. A. Parker
    • 2
  • J. R. Duncan
    • 1
  • L. W. Schierman
    • 2
  1. 1.Department of Veterinary Pathology, College of Veterinary MedicineUniversity of GeorgiaAthensUSA
  2. 2.Department of Avian Medicine, College of Veterinary MedicineUniversity of GeorgiaAthensUSA

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