Acta Neuropathologica

, Volume 61, Issue 3–4, pp 253–257

Prolactinoma coexistent with granulomatous hypophysitis

  • S. Holck
  • H. Laursen
Original Works

Summary

A 54-year-old man with a long-lasting left-sided headache and biochemical evidence of hyperprolactinemia was found to have a large chromophobe pituitary adenoma, which concurred with a granulomatous hypophysitis. The mechanism of the inflammatory reaction is discussed and the immunohistochemical and ultrastructural findings of this hitherto undescribed combination of lesions are presented.

Key words

Pituitary adenoma Prolactinoma Granulomatous hypophysitis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bleisch VR, Robbins SL (1952) Sarcoid-like granulomata of the pituitary gland. Arch Int Med 89:877–892Google Scholar
  2. Braylan RC, Long IC, Jaffe ES et al (1977) Malignant lymphoma obsured by concomitant extensive epithelioid granulomas. Cancer 39:1146–1155Google Scholar
  3. Cabanne F, Dusserre P, Michiels R (1963) Phospholipides et stroma-reáction cancéreuse à cellules epithélioides. Aperçu anatomopathologique, biochimique et expérimental. Ann Anat Pathol (Paris) 8:245–273Google Scholar
  4. Delarue J, Chomette G, Brochériou C (1963) Granulome hypophysaire à cellules géantes. Arch Anat Pathol (Paris) 11:185–188Google Scholar
  5. Doniach I, Wright EA (1951) Two cases of giant-cell granuloma of the pituitary gland. J Pathol Bacteriol 63:69–79Google Scholar
  6. Ferlito A, Recher G (1980) Ackerman's tumor (verrucous carcinoma) of the larynx. Cancer 46:1617–1630Google Scholar
  7. Fink EB (1933) Gumma of the hypophysis and hypothalamus. Arch Pathol 15:631–635Google Scholar
  8. Kirschbaum JD, Levy HA (1941) Tuberculoma of hypophysis with insufficiency of anterior lobe. Arch Int Med 68:1095–1104Google Scholar
  9. Kovacs K, Horvath E, Ezrin C (1977) Pituitary adenomas. Pathol Annu 12:341–382Google Scholar
  10. Laurberg P (1975) Sarcoid reactions in pulmonary neoplasms. Scand J Resp Dis 56:20–27Google Scholar
  11. Lundberg PO, Osterman PO, Wide L (1981) Serum prolactin in patients with hypothalamus and pituitary disorders. J Neurosurg 55:194–199Google Scholar
  12. Lucien M, Parisot J (1909) Tuberculose de l'hypophyse et diabète sucré. Rev Neurol 17:970–975Google Scholar
  13. Oelbaum MH, Wainwright J (1950) Hypopituitarism in a male due to giant cell granuloma of the anterior pituitary. J Clin Pathol 3:122–129Google Scholar
  14. Pak HY, Friedman NB (1981) Pseudosarcoid granulomas in Hodgkin's disease. Human Pathol 12:832–837Google Scholar
  15. Pappenheim M (1934) Welches Krankheitsbild bietet die hypophysäre Kachexie? Wien Klin Wochenschr 47:148–150Google Scholar
  16. Rickards AG, Harvey PW (1954) Giant cell granuloma' and the other pituitary granulomata. Q J Med 23:425–439Google Scholar
  17. Sacks EL, Donaldson SS, Gordon J, Dorfman RF (1978) Epithelioid granulomas associated with Hodgkin's disease. Cancer 41:562–567Google Scholar
  18. Sandison AT (1956) Giant-cell granuloma of the pituitary gland. Scott Med J 1:184–185Google Scholar
  19. Sheehan HL, Summers VK (1949) The syndrome of hypopituitarism. Q J Med 18:319–378Google Scholar
  20. Simmonds M (1917) Über das Vorkommen von Riesenzellen in der Hypophyse. Virchows Arch [Pathol Anat] 223:281–290Google Scholar
  21. Teilum G (1951) Glomerular lesions of the kidneys in sarcoidosis (Boeck's sarcoid). Acta Pathol Microbiol Scand 28:294–301Google Scholar
  22. Tfelt-Hansen P, Paulson OB, Krabbe Æ (1982) Invasive adenoma of the pituitary gland and chronic migrainous neuralgia. A rare coincidence or a causal relationship? Cephalalgia 2:25–28Google Scholar
  23. Turkington RW, Underwood LE, Van Wyk JJ (1971) Elevated serum prolactin levels after pituitary-stalk section in man. N Engl J Med 285:707–710Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • S. Holck
    • 1
  • H. Laursen
    • 2
  1. 1.Dept. of PathologyRigshospitaletCopenhagen ØDenmark
  2. 2.Dept. of NeuropathologyUniversity of CopenhagenCopenhagenDenmark

Personalised recommendations