Acta Neuropathologica

, Volume 44, Issue 2, pp 163–165 | Cite as

Lymphocytes within glial cells (“emperipolesis”) in a case of a granular cell tumor

  • W. Müller
  • H. G. Dahmen
Short Original Communications


A case of a combined neurofibroma —granular cell tumor of the left middle cranial fossa with infiltration of the temporal lobe and expansion into the orbit is presented. The granular cell tumor shows big fibrillary astrocytes in its peripheral zone. Even in the tumor-free brain tissue adjacent to the tumor plenty of these obviously reactively proliferated astrocytes are found. Furthermore, lymphocytes within the cytoplasm of such astrocytes (“emperipolesis”) strike the eye. Neither the lymphocytes nor the astrocytes show signs of damage. A review of the literature and the theorics concerning the phenomenon of emperipolesis are given. The problem of its biological significance and the question whether emperipolesis is the result of invasion or engulfment must remain unsolved.

Key words

Granular cell tumor Reactive astrocytic proliferation Emperipolesis in astrocytes 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • W. Müller
    • 1
  • H. G. Dahmen
    • 1
  1. 1.Department of Pathology of CologneJoseph-Stelzmann-Str. 9Köln 41Germany

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