Journal of Comparative Physiology B

, Volume 158, Issue 4, pp 495–500 | Cite as

Time-course of blood acid-base state during arousal from hibernation in the European hamster

  • A. Malan
  • E. Mioskowski
  • C. Calgari
Article

Summary

  1. 1.

    Arterial blood was sampled at 15 min-intervals in European hamstersCricetus cricetus fitted with indwelling catheters, from deep hibernation to full arousal. Temperature-corrected pH andPCO2, respectively pH* andP*CO2, were directly measured at 37 °C.

     
  2. 2.

    Deep hibernation corresponded to a respiratory acidosis: pH*=7.01±0.01 (mean±SE),P*CO2=160±4 Torr (n=9 animals).

     
  3. 3.

    Three periods could be distinguished in the arousal: (i) a period of hyperventilation (28±5 min), in whichP*CO2 was reduced to 79±4 Torr, while cheek pouch temperature increased only by 0.9±0.2 °C; (ii) a period of metabolic acidification by lactate accumulation (84±6 min), corresponding to the period of peak thermogenesis; (iii) a progressive return to euthermic conditions (104±10 min), by simultaneous respiratory and metabolic alkalinization.

     
  4. 4.

    Over 60% of the blood CO2 stores accumulated at the beginning of the hibernation bout were released by hyperventilation during the first period, prior to the full development of thermogenesis. This is in agreement with the hypothesis of an inhibitory role of the respiratory acidosis in hibernation.

     

Abbreviations

[HCO3−*

bicarbonate concentration, corrected to the reference temperature, here 37 °C

MCO2

carbon dioxide production per unit time

MO2

oxygen consumption per unit time

P*CO2

temperature-corrected partial pressure of CO2

pH*

temperature-corrected pH

Tb

body temperature

Tcp

cheek pouch temperature

VE

expiratory flow rate

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • A. Malan
    • 1
  • E. Mioskowski
    • 1
  • C. Calgari
    • 1
  1. 1.Laboratoire d'Etude des Régulations Physiologiques (associated with Université Louis Pasteur)CNRSStrasbourgFrance

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