Acta Neuropathologica

, Volume 42, Issue 2, pp 127–134 | Cite as

Lewy bodies in cerebral cortex. Report of three cases

  • Kenji Kosaka
Original Investigations


The histochemical and structural properties and the topographical distribution pattern of Lewy bodies in the cerebral cortex as well as in the brain stem and diencephalon were studied in three cases.

The Lewy bodies in the cerebral cortex were found in the small or medium-sized neurons of the fifth and sixth layers, particularly in the anterior frontal, temporal, insular, and cingulate cortex, and showed minor differences in their histochemical and structural properties from typical Lewy bodies in the brain stem and diencephalon. By light microscopy they were more irregular in shape, less eosinophilic, less sharply demarcated, and did not have clear halos and central cores. From the ultrastructural aspect, the filaments in them did not radiate, but were arranged at random, and circular profiles were not associated in the central zone. This type of Lewy body was also distributed in the basal ganglia. A close relationship between Lewy bodies and monoamines in the cerebral cortex of our cases was not recognized. These three cases showed also concomitant senile changes, i.e., senile plaques and neurofibrillary tangles.

Key words

Lewy body “Cerebral type” of Lewy body Monoamines Dementia Senile changes 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Kenji Kosaka
    • 1
  1. 1.Division of NeuropathologyPsychiatric Research Institute of TokyoTokyoJapan

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