Spongiform-like changes in Alzheimer's disease
- 53 Downloads
The ultrastructural study of the cortex of four patients with sporadic or familial AD, of two agematched controls without dementia, and of one normal pressure hydrocephalus, revealed in all the cases in the neuropil only occasional vacuoles which had a morphology similar to those observed in CJD. The degree of spongiform-like changes was, however, far less prominent than in CJD and considered mild in all the cases examined. Moreover, curled fragments of membranes within the vacuoles were not observed. It is suggested that the mild vacuolization of the neuropil occasionally observed in cortical biopsies of AD is a non-specific finding and cannot be considered a neuropathologic link between AD and CJD.
Key wordsAlzheimer's disease Creutzfeldt-Jakob disease Spongiform changes Electron microscopy
Unable to display preview. Download preview PDF.
- Cook RH, Ward BE, Austin JH (1979) Studies in aging of the brain: IV. Familial Alzheimer disease: Relation to transmissible dementia, aneuploidy, and microtubular defects. Neurology 29:1402–1412Google Scholar
- Flament-Durand J, Couck AM (1979) Spongiform alterations in brain biopsies of presenile dementia. Acta Neuropathol (Berl) 46:159–162Google Scholar
- Gaches J, Supino-Viterbo V, Foncin JF (1977) Association de maladies d'Alzheimer et de Creutzfeld-Jakob. Acta Neurol Belg 77:202–212Google Scholar
- Gibbs CJ, Gajdusek DC (1978) Subacute spongiform virus encephalopathies: the transmissible virus dementias. In: Katzman R, Terry RD, Bick KL (eds) Alzheimer's disease: Senile dementia and related disorders, aging, vol 7. Raven Press, New York, pp 559–577Google Scholar
- Goudsmit J, Morrow CH, Asher DM, Yanagihara RT, Masters CL, Gibbs CJ, Jr, Gajdusek DC (1980) Evidence for and against the transmissibility of Alzheimer's disease. Neurology 30:945–950Google Scholar
- Lampert PW, Gajdusek DC, Gibbs CJ, Jr (1971) Experimental spongiform encephalopathy (Creutzfeldt-Jakob disease) in chimpanzees: Electron microscopic studies. J Neuropathol Exp Neurol 30:20–32Google Scholar
- Masters CL, Gajdusek DC, Gibbs CJ, Jr, Bernoulli C, Asher DM (1979) Familial creutzfeldt-Jakob disease and other familial dementias: An inquiry into possible modes of transmission of virus-induced familial diseases. In: Prusiner SB, Hadlow WJ (eds) Slow transmissible diseases of the nervous system, vol 1, Academic Press, New York, pp 143–194Google Scholar
- Masters CL, Richardson EP, Jr (1978) Subacute spongiform encephalopathy (Creutzfeldt-Jakob disease). The nature and progression of spongiform change. Brain 101:333–344Google Scholar
- Rewcastle NB, Gibbs CJ, Jr, Gajdusek DC (1978) Transmission of familila Alzheimer's disease to primates. J Neuropathol Exp Neurol 37:679Google Scholar